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Journal Articles Computers in Biology and Medicine Year : 2018

Mechanistic modelling of drug release from multi-layer capsules

Abstract

We propose a novel in silico model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we solve analytically using separation of variables. In addition to the conventional partitioning and mass transfer interlayer conditions, we consider a surface finite mass transfer resistance, which corresponds to the case of a coated capsule. The drug concentration in the core and through all the layers, as well as in the external release medium, is given in terms of a Fourier series that we compute numerically to describe and characterize the drug release mechanism.
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Dates and versions

hal-01735775 , version 1 (16-03-2018)

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Badr Kaoui, Marco Lauricella, Giuseppe Pontrelli. Mechanistic modelling of drug release from multi-layer capsules. Computers in Biology and Medicine, 2018, 93, pp.149 - 157. ⟨10.1016/j.compbiomed.2017.12.010⟩. ⟨hal-01735775⟩
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