Article Dans Une Revue EPL - Europhysics Letters Année : 2017

Non-equilibrium fluctuations of a semi-flexible filament driven by active cross-linkers

Résumé

The cytoskeleton is an inhomogeneous network of semi-flexible filaments, which are involved in a wide variety of active biological processes. Although the cytoskeletal filaments can be very stiff and embedded in a dense and cross-linked network, it has been shown that, in cells, they typically exhibit significant bending on all length scales. In this work we propose a model of a semi-flexible filament deformed by different types of cross-linkers for which one can compute and investigate the bending spectrum. Our model allows to couple the evolution of the deformation of the semi-flexible polymer with the stochastic dynamics of linkers which exert transversal forces onto the filament. We observe a $q^{-2}$ dependence of the bending spectrum for some biologically relevant parameters and in a certain range of wavenumbers $q$. However, generically, the spatially localized forcing and the non-thermal dynamics both introduce deviations from the thermal-like $q^{-2}$ spectrum.

Dates et versions

hal-01716271 , version 1 (23-02-2018)

Identifiants

Citer

Ines Weber, Cecile Appert-Rolland, Gregory Schehr, Ludger Santen. Non-equilibrium fluctuations of a semi-flexible filament driven by active cross-linkers. EPL - Europhysics Letters, 2017, 120 (3), pp.38006. ⟨10.1209/0295-5075/120/38006⟩. ⟨hal-01716271⟩
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