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Communication Dans Un Congrès Année : 2014

An artificial primitive mimic of Gramicidin-A channel

Résumé

Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or ‘T-channel’ forming compound (TCT), having similar constitutional functions as the natural gAs. As in gA channels, the carbonyl moieties of the TCT, which point toward the T-channel core and surround the transport direction, are solvated by water. The net-dipolar alignment of water molecules along the chiral pore surfaces influences the conduction of protons/ions, envisioned to diffuse along dipolar hydrophilic pathways. Theoretical simulations and experimental assays reveal that the conduction through the T-channel, similar to that in gA, presents proton/water conduction, cation/anion selectivity and large open channel-conductance states. T-channels—associating supramolecular chirality with dipolar water alignment—represent an artificial primitive mimic of gA.

Domaines

Chimie

Dates et versions

hal-01715516 , version 1 (22-02-2018)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Mihail Barboiu, Arnaud Gilles, Pierre-André Cazade, Mathieu Michau, Benoit Coasne, et al.. An artificial primitive mimic of Gramicidin-A channel. 10th International Congress on Membrane and Membrane Processes - ICOM 2014, Jul 2014, Suzhou, China. ⟨10.1038/ncomms5142⟩. ⟨hal-01715516⟩
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