Opioid substitution therapy or hidden opioids are a minefield for nalmefene: an atypical case series of 11 patients in Lorraine - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Fundamental & Clinical Pharmacology Année : 2017

Opioid substitution therapy or hidden opioids are a minefield for nalmefene: an atypical case series of 11 patients in Lorraine

Résumé

Opioid antagonists such as naltrexone and nalmefene are used in drug therapy for alcoholism. Nalmefene, approved in Europe in February 2013 for the reduction of alcohol consumption, is used in patients with alcohol dependence. We report 11 cases of opioid withdrawal syndrome after a single dose of nalmefene in patients usually treated with methadone, buprenorphine, but also with fentanyl or loperamide. Nalmefene is both a partial agonist and an antagonist of opioid receptors. Regarding to its opioid antagonist activity, nalmefene is contraindicated in patients with an opioid treatment. Therefore, when prescribing or delivering nalmefene, healthcare professionals need to be vigilant about any type of opioid exposure, even masked or hidden, to avoid these potential life-threatening syndromes.
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Dates et versions

hal-01713582 , version 1 (20-02-2018)

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Melissa Yelehe-Okouma, Hervé Martini, Jérémie Lemarié, Pierre Labroca, Nadine Petitpain, et al.. Opioid substitution therapy or hidden opioids are a minefield for nalmefene: an atypical case series of 11 patients in Lorraine. Fundamental & Clinical Pharmacology, 2017, 31 (5), pp.574 - 579. ⟨10.1111/fcp.12286⟩. ⟨hal-01713582⟩
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