The increased risk of plantar ulceration in patients with diabetic polyneuropathy (DPN) is often associated with an heterogeneous plantar pressure distribution characterized by overloading the anterior regions, unloading the toes and hallux, and a reduced role of lateral forefoot and toes. he most studied loading variables in this population are mean and standard deviation of peak pressure and pressure-time integral, that reduces the complex and interdependent foot segments dynamics to a simple average value of many steps, that is also represented by only one sensor. Therefore, they are not optimal variables for describing time changes during the whole process of foot-floor interaction. Our aim is to propose a method for identifying plantar areas that most discriminate the overall changes through time in the plantar pressure distribution during gait, after an exercise intervention protocol for DPN patients