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Article Dans Une Revue FEBS Journal Année : 2017

AIDing-targeted protein degradation in Drosophila

Xu Zhang
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Résumé

Conditional protein depletion is highly desirable for investigating protein functions in complex organisms. In this issue, Bence and colleagues combined auxin-inducible degradation with CRISPR, establishing an elegant tool to control protein levels. They achieve precise spatio-temporal control of protein degradation during Drosophila oogenesis and early embryogenesis by combining suitable GAL4 drivers (spatial control) with auxin feeding protocols (temporal control).

Dates et versions

hal-01690429 , version 1 (23-01-2018)

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Xu Zhang, Frank Schnorrer. AIDing-targeted protein degradation in Drosophila. FEBS Journal, 2017, 284 (8), pp.1178 - 1181. ⟨10.1111/febs.14054⟩. ⟨hal-01690429⟩
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