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                <term xml:lang="en">mice</term>
                <term xml:lang="en">Neuronal activity modulation</term>
                <term xml:lang="en">c-Fos</term>
                <term xml:lang="en">Bioactive peptide</term>
                <term xml:lang="en">alpha-Casozepine</term>
                <term xml:lang="en">Anxiety</term>
                <term xml:lang="fr">souris</term>
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              <p>alpha-Casozepine, a bioactive peptide from milk casein, displays an anxiolytic-like activity in many species. Since its mode of action is still not elucidated, a study was conducted in Swiss mice to investigate c-Fos expression, a marker of neuronal activity, in different brain areas. After an intraperitoneal injection of alpha-casozepine (1 mg/kg), animals were placed either in a non-stressful or in an anxiety-inducing situation triggered with a light/dark box. No effect of alpha-casozepine on c-Fos expression was observed in the non-stressful situation. In the stressful situation, modulation of neuronal activity by alpha-casozepine was observed in different brain regions compared to that of vehicle. However, while diazepam, a benzodiazepine, modulated neuronal activity the same way in hippocampus, accumbens nucleus and hypothalamus, differences were observed in c-Fos expression in amygdala and prefrontal cortex compared to alpha-casozepine. These results strengthen the assumption that the anxiolytic mechanisms of alpha-casozepine differ partly of those of diazepam.</p>
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