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Article Dans Une Revue Biomarkers Année : 2017

P-gp expression levels in the erythrocytes of brown trout: a new tool for aquatic sentinel biomarker development

Résumé

P-glycoprotein (P-gp) is a ubiquitous membrane detoxification pump involved in cellular defence against xenobiotics. Blood is a hub for the trade and transport of physiological molecules and xenobiotics. Our recent studies have highlighted the expression of a 140-kDa P-gp in brown trout erythrocytes in primary cell culture and its dose-dependent response to Benzo[a]pyrene pollutant.

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hal-01675152 , version 1 (04-01-2018)

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Emeline Valton, Ivan Wawrzyniak, Christian Amblard, Bruno Combourieu, Marie-Laure Bayle, et al.. P-gp expression levels in the erythrocytes of brown trout: a new tool for aquatic sentinel biomarker development. Biomarkers, 2017, 22 (6), pp.566 - 574. ⟨10.1080/1354750X.2017.1338314⟩. ⟨hal-01675152⟩
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