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Journal Articles Diagnostic Microbiology and Infectious Disease Year : 2017

Large-scale evaluation of a rapid diagnostic test for human cystic echinococcosis

Large-scale evaluation of a rapid diagnostic test for human cystic echinococcosis.

Abstract

Cystic echinococcosis (CE) is a neglected zoonotic disease, diagnosed through clinical findings, imaging techniques, and serology, for which many serological tests are available. Here we report a rapid unit assay, the immunochromatographic VIRapid® HYDATIDOSIS test (Vircell, Granada, Spain), potentially suitable for laboratories in low-prevalence or poorly equipped areas. This test was evaluated with a large retrospective cohort (224 sera), including patients suffering from CE or from other parasitic or liver diseases. The test was also assessed in routine conditions with a prospective cohort (115 sera) in areas where both cystic and alveolar echinococcoses have been diagnosed. Its performance (in terms of sensitivity, specificity, and both positive and negative likelihood ratios) was similar to an ELISA based on a crude antigen. Our study shows that this test performs adequately in the diagnostic process, when used with caution, especially regarding cross-reactivity with other parasitic diseases.

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Health
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Dates and versions

hal-01667577 , version 1 (19-12-2017)

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Alice Baraquin, Houria Zait, Florence-Elisabeth Grenouillet, Elise Moreau, Boussad Hamrioui, et al.. Large-scale evaluation of a rapid diagnostic test for human cystic echinococcosis. Diagnostic Microbiology and Infectious Disease, 2017, 89 (1), pp.20 - 25. ⟨10.1016/j.diagmicrobio.2017.06.002⟩. ⟨hal-01667577⟩
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