Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives

A series of 1-acyl-4-sulfonylpiperazine derivatives has been prepared. The antiproliferative effect of these compounds was evaluated in vitro against human prostate cancer cell line C4-2, several among them exhibited interesting growth inhibitory against this particular cell line. Finally, a molecular modeling study was employed to analyze the structure/activity relationships (SAR) of these novel compounds..

Mots clés

1-acyl-4-sulfonylpiperazines Prostate cancer Antiproliferative activity Molecular modelling SAR

Domaines

Chimie organique Chimie thérapeutique Cancer Chemo-informatique

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synthesis-anticancer-activity-and-computational-sar-analysis-ofacylsulfonylpiperazines-derivatives-2161-0444-1000466(1).pdf (968.69 Ko)

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Soumis le : mercredi 13 décembre 2017-09:54:29

Dernière modification le : mardi 22 octobre 2024-12:18:03

Dates et versions

hal-01662364 , version 1 (13-12-2017)

Identifiants

HAL Id : hal-01662364 , version 1
DOI : 10.4172/2161-0444.1000466

Citer

Zohra Benfodda, Vanessa Fritz, Corinne Henriquet, Caterina Fattorusso, Gerardo Cebrian Cebrian-Torrejon, et al.. Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives. Medicinal Chemistry, 2017, 7 (9), pp.257-267. ⟨10.4172/2161-0444.1000466⟩. ⟨hal-01662364⟩

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