Control of fluxes in metabolic networks - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Genome Research Année : 2016

Control of fluxes in metabolic networks

Georg Basler
  • Fonction : Auteur
Zoran Nikoloski
  • Fonction : Auteur
  • PersonId : 911104
Albert-László Barabási
  • Fonction : Auteur
Yang-Yu Liu

Résumé

Understanding the control of large-scale metabolic networks is central to biology and medicine. However, existing approaches either require specifying a cellular objective or can only be used for small networks. We introduce new coupling types describing the relations between reaction activities, and develop an efficient computational framework, which does not require any cellular objective for systematic studies of large-scale metabolism. We identify the driver reactions facilitating control of 23 metabolic networks from all kingdoms of life. We find that unicellular organisms require a smaller degree of control than multicellular organisms. Driver reactions are under complex cellular regulation in Escherichia coli, indicating their preeminent role in facilitating cellular control. In human cancer cells, driver reactions play pivotal roles in malignancy and represent potential therapeutic targets. The developed framework helps us gain insights into regulatory principles of diseases and facilitates design of engineering strategies at the interface of gene regulation, signaling, and metabolism.

Dates et versions

hal-01658343 , version 1 (07-12-2017)

Identifiants

Citer

Georg Basler, Zoran Nikoloski, Abdelhalim Larhlimi, Albert-László Barabási, Yang-Yu Liu. Control of fluxes in metabolic networks. Genome Research, 2016, 26 (7), pp.956 - 968. ⟨10.1101/gr.202648.115⟩. ⟨hal-01658343⟩
118 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More