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Article Dans Une Revue Brain Topography: a Journal of Cerebral Function and Dynamics Année : 2017

Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation

Marc Rey
  • Fonction : Auteur
Catherine Cassé-Perrot
  • Fonction : Auteur
Franck Rouby
  • Fonction : Auteur
Marie-Noëlle Lefebvre
  • Fonction : Auteur
Christine Audebert
  • Fonction : Auteur
Pierre Payoux
Jill C. Richardson
  • Fonction : Auteur
Joelle Micallef
  • Fonction : Auteur
Pharmacog Consortium
  • Fonction : Auteur

Résumé

Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer's disease, the analysis of networks altered by medication would be particularly interesting. Eleven healthy subjects were recruited in the context of the European Innovative Medicines Initiative 'PharmaCog'. Each underwent five sessions of simultaneous EEG-fMRI in order to investigate the effects of donepezil and memantine before and after sleep deprivation (SD). The SD approach has been previously proposed as a model for cognitive impairment in healthy subjects. By applying network based statistics (NBS), we observed altered brain networks significantly linked to donepezil intake and sleep deprivation. Taking into account the sleep stages extracted from the EEG data we revealed that a network linked to sleep is interacting with sleep deprivation but not with medication intake. We successfully extracted the functional resting-state networks modified by donepezil intake, sleep and SD. We observed donepezil induced whole brain connectivity alterations forming a network separated from the changes induced by sleep and SD, a result which shows the utility of this approach to check for the validity of pharmacological resting-state analysis of the tested medications without the need of taking into account the subject specific vigilance.
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Dates et versions

hal-01657955 , version 1 (07-12-2017)

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Citer

Jonathan Wirsich, Marc Rey, Maxime Guye, Christian Bénar, Laura Lanteaume, et al.. Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation. Brain Topography: a Journal of Cerebral Function and Dynamics, 2017, ⟨10.1007/s10548-017-0608-5⟩. ⟨hal-01657955⟩
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