Cobalt( iii )porphyrin to target G-quadruplex DNA - Archive ouverte HAL
Article Dans Une Revue Dalton Transactions Année : 2015

Cobalt( iii )porphyrin to target G-quadruplex DNA

Résumé

G-quadruplex DNA ligands attract much attention because of their potential use in biology. Indeed they may interfere with G-quadrulex nucleic acid function in cells. Most of the G-quadruplex ligands so far reported (including also metal complexes) are large planar aromatic compounds that interact by π–π stacking with an external G-quartet of quadruplex. Porphyrins are well-known G-quadruplex ligands. We report herein a new porphyrin scaffold (meso-tetrakis(4-(N-methyl-pyridinium-2-yl)phenyl)porphyrin) able to strongly and selectively bind to G-quadruplex DNA. We show that even when this porphyrin is metallated with cobalt(III), i.e. it carries two water molecules as axial ligands on the cobalt ion, on each face of the porphyrin, the interaction occurs by a π-stacking-like mode with an external G-quartet of quadruplex DNA.

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Dates et versions

hal-01650937 , version 1 (28-11-2017)

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Laurent Sabater, Pei-Ju Fang, Chi-Fon Chang, Aurore de Rache, Enora Prado, et al.. Cobalt( iii )porphyrin to target G-quadruplex DNA. Dalton Transactions, 2015, 44 (8), pp.3701 - 3707. ⟨10.1039/c4dt03631j⟩. ⟨hal-01650937⟩
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