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            <title xml:lang="en">Relationship with the Position of the Central Retinal Vessel Trunk</title>
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                <forename type="first">Baek-Lok</forename>
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                <forename type="first">Eun Ji</forename>
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                <forename type="first">Hyunjoong</forename>
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                <forename type="first">Michaël J A</forename>
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                <title xml:lang="en">Relationship with the Position of the Central Retinal Vessel Trunk</title>
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                  <persName>
                    <forename type="first">Baek-Lok</forename>
                    <surname>Oh</surname>
                  </persName>
                  <idno type="halauthorid">1259389-0</idno>
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                  <persName>
                    <forename type="first">Eun Ji</forename>
                    <surname>Lee</surname>
                  </persName>
                  <idno type="halauthorid">1259390-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hyunjoong</forename>
                    <surname>Kim</surname>
                  </persName>
                  <idno type="halauthorid">1259391-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michaël J A</forename>
                    <surname>Girard</surname>
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                  <idno type="halauthorid">926753-0</idno>
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                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Martial</forename>
                    <surname>Mari</surname>
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                    <forename type="first">Tae-Woo</forename>
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                  <publisher>Public Library of Science</publisher>
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                  <date type="datePub">2016-06-29</date>
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                <term xml:lang="en">DEFORMATION</term>
                <term xml:lang="en">COMPONENTS</term>
                <term xml:lang="en">ENHANCEMENT</term>
                <term xml:lang="en">DISPLACEMENT</term>
                <term xml:lang="en">EXTRACELLULAR-MATRIX</term>
                <term xml:lang="en">HUMAN EYES</term>
                <term xml:lang="en">NERVE HEAD</term>
                <term xml:lang="en">AGE-RELATED-CHANGES</term>
                <term xml:lang="en">INTRAOCULAR-PRESSURE ELEVATION</term>
                <term xml:lang="en">OPTICAL COHERENCE TOMOGRAPHY</term>
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              <p>PurposeTo determine the factors influencing the anterior lamina cribrosa (LC) surface depth (LCD) in patients with open-angle glaucoma (OAG), focusing on the association between LCD and the position of the central retinal vessel trunk (CRVT) at the anterior LC surface.MethodsOptic nerve heads of 205 OAG eyes were scanned using swept-source optical coherence tomography (SS-OCT). After processing the images using adaptive compensation, the LCD was determined from 11 horizontal B-scan images that divided the optic disc vertically into 12 equal parts. Eyes were divided into two groups (central or peripheral) according to where the CRVT exits from the anterior LC surface. The influence of CRVT position on LCD was evaluated, taking into account age, gender, untreated intraocular pressure (IOP), IOP at optic-disc scanning, retinal nerve fiber layer (RNFL) thickness, visual-field mean deviation, central corneal thickness, and axial length.ResultsPatients in the peripheral CRVT group were younger and more myopic, and had a larger mean LCD and thinner global RNFL than those in the central CRVT group (all P &lt;= 0.023). On multivariate analysis, the peripheral CRVT location was significantly associated with a larger LCD (P = 0.002), together with the significant association of younger age (P &lt; 0.001), higher untreated IOP (P = 0.010), and thinner RNFL (P = 0.003) on the larger LCD.ConclusionIn OAG, CRVT location was an independent factor influencing the LCD, together with age, untreated IOP, and global RNFL thickness. The data indicate that the CRVT may contribute to the resistance of the LC against deformation. A longitudinal prospective observation is required to clarify this relationship.</p>
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          <orgName>National University of Singapore</orgName>
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