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                <title xml:lang="fr">Détermination des propriétés élastiques de l’os trabéculaire à l’échelle micro- et macroscopique par la méthode des microéléments finis</title>
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              <p>Objective of the study: The objective of the present study is to assess the mechanical behavior of trabecular bone based on microCT imaging and micro-finite-element analysis. In this way two methods are detailed: (i) direct determination of macroscopic elastic property of trabecular bone; (ii) inverse approach to assess mechanical properties of trabecular bone tissue.Patients: Thirty-five females and seven males (forty-two subjects) mean aged (± SD) 80 ± 11.7 years from hospitals of Assistance publique–Hôpitaux de Paris (AP–HP) diagnosed with osteoporosis following a femoral neck fracture due to a fall from standing were included in this study.Materials and methods: Fractured heads were collected during hip replacement surgery. Standardized bone cores were removed from the femoral head's equator by a trephine in a water bath. MicroCT images acquisition and analysis were performed with CTan® software and bone volume fraction was then determined. Micro-finite-element simulations were per-formed using Abaqus 6.9-2® software in order to determine the macroscopic mechanical behaviour of the trabecular bone. After microCT acquisition, a longitudinal compression test was performed and the experimental macroscopic Young's Modulus was extracted. An inverse approach based on the whole trabecular bone's mechanical response and micro-finite-element analysis was performed to determine microscopic mechanical properties of trabecular bone.Results: In the present study, elasticity of the tissue was shown to be similar to that of healthy tissue but with a lower yield stress.Conclusion: Classical histomorphometric analysis form microCT imaging associated with an inverse micro-finite-element method allowed to assess microscopic mechanical trabecular bone parameters</p>
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              <p>Objectif de l’étude: Déterminer le comportement mécanique de l’os trabéculaire à l’aide d’une acquisition microtomographique par rayons X et d’une analyse par la méthode des microéléments finis : (i) détermination directe du module d’élasticité apparent de l’os trabéculaire ; (ii) approche inverse pour déterminer les propriétés mécaniques du tissu trabéculaire.Patients: Trente-cinq femmes et 7 hommes d’âge moyen 80 ± 11,7 ans de l’Assistance publique–Hôpitaux de Paris diagnostiqués ostéoporotiques suite à une fracture de l’extrémité supérieure du fémur due à une chute.Matériels et méthodes: Suite à une arthroplastie, des carottes osseuses ont été extraites au sommet de la tête fémorale à l’aide d’un trépan. Une acquisition microtomographique aux rayons X et une analyse des paramètres histomorphométriques ont ensuite été effectuées. Par la suite, le comportement macroscopique de l’os trabéculaire a été déterminé par la méthode des microéléments finis sur le logiciel Abaqus 6.9-2®. Un essai de compression longitudinale a ensuite été réalisé afin de mesurer le module d’élasticité apparent. Enfin, une analyse inverse basée sur le comportement mécanique expérimental apparent combinée à la méthode des microéléments finis a permis de déterminer le comportement microscopique de l’os trabéculaire.Résultats: Les résultats ont montré que les propriétés élastiques de l’os trabéculaire présentaient les mêmes caractéristiques que chez des patients sains.Conclusion: La méthode classique d’histomorphométrie combinée à une méthode inverse des microéléments finis permet de remonter aux propriétés élastiques microscopiques de l’os trabéculaire.</p>
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