Synthesis of a New Linear-Cyclic Ditopic Polyazaligand with a Xylenyl Linker
Résumé
The synthesis of a new linear-cyclic ditopic polyazaligand with a xylenyl linker 1 is described. The sequence is based on the stoichiometric reaction of a dissymmetrical biselectrophilic reagent, p-(chloromethyl)benzyl-p-toluenesulfonate, with phosphorylcyclam to give rise to an original intermediate possessing a p-chloroxylenyl pendant arm. The subsequent reaction of this compound with glyoxal-protected linear tetraamine, followed by deprotection steps, leads to the desired ditopic ligand with a good overall yield