Biocompatible Periodic Mesoporous Ionosilica Nanoparticles with Ammonium Walls: Application to Drug Delivery
Résumé
Periodic mesoporous ionosilica nanoparticles with ammonium walls
were synthesized exclusively from a trisilylated ammonium precursor. The nanoparticles
display a uniform particle size, together with a high specific surface area and an
ordered hexagonal pore architecture. Completely biocompatible in vitro and in vivo,
the nanoparticles are efficiently endocytosed by RAW 264.7 macrophages and used as
carrier vehicles for anionic drugs. Diclofenac-loaded ionosilica nanoparticles are very
efficient in inhibiting lipopolysaccharides-induced inflammation.