<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01625025</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T23:23:27+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Solvent-free mechanochemical route for green synthesis of pharmaceutically attractive phenolhydrazones</title>
            <author role="aut">
              <persName>
                <forename type="first">Paulo F. M.</forename>
                <surname>Oliveira</surname>
              </persName>
              <idno type="halauthorid">1245286-0</idno>
              <affiliation ref="#struct-242220"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Baron</surname>
              </persName>
              <email type="md5">c6f155dbc19f32e9273c860862c286f2</email>
              <email type="domain">mines-albi.fr</email>
              <idno type="idhal" notation="string">michel-baron</idno>
              <idno type="idhal" notation="numeric">15986</idno>
              <idno type="halauthorid" notation="string">6855-15986</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9981-9910</idno>
              <idno type="IDREF">https://www.idref.fr/078055148</idno>
              <orgName ref="#struct-469216"/>
              <affiliation ref="#struct-242220"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Chamayou</surname>
              </persName>
              <email type="md5">fff55c9735559609016246fbad0282d2</email>
              <email type="domain">mines-albi.fr</email>
              <idno type="idhal" notation="string">alain-chamayou</idno>
              <idno type="idhal" notation="numeric">179101</idno>
              <idno type="halauthorid" notation="string">39904-179101</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2060-1837</idno>
              <idno type="IDREF">https://www.idref.fr/08318080X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAL-1317-2020</idno>
              <orgName ref="#struct-469216"/>
              <affiliation ref="#struct-242220"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christiane</forename>
                <surname>André-Barrès</surname>
              </persName>
              <email type="md5">cb372e213eff46198c8bb7805c67cab8</email>
              <email type="domain">chimie.ups-tlse.fr</email>
              <idno type="idhal" notation="string">christiane-andre-barres</idno>
              <idno type="idhal" notation="numeric">178205</idno>
              <idno type="halauthorid" notation="string">19450-178205</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8973-1875</idno>
              <idno type="IDREF">https://www.idref.fr/084177942</idno>
              <affiliation ref="#struct-571"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Brigitte</forename>
                <surname>Guidetti</surname>
              </persName>
              <idno type="halauthorid">1251985-0</idno>
              <affiliation ref="#struct-571"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Baltas</surname>
              </persName>
              <email type="md5">bff7b022110adb42ebd583271ade1883</email>
              <email type="domain">lcc-toulouse.fr</email>
              <idno type="idhal" notation="string">michel-baltas</idno>
              <idno type="idhal" notation="numeric">178036</idno>
              <idno type="halauthorid" notation="string">6516-178036</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8785-7095</idno>
              <idno type="IDREF">https://www.idref.fr/03195314X</idno>
              <affiliation ref="#struct-571"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>IMT Mines Albi</forename>
                <surname>IMT Mines Albi</surname>
              </persName>
              <email type="md5">baf60d7e7735a25e40463f14664b1afd</email>
              <email type="domain">mines-albi.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-11-08 10:03:24</date>
              <date type="whenModified">2026-02-07 05:17:34</date>
              <date type="whenReleased">2019-11-12 09:17:07</date>
              <date type="whenProduced">2014</date>
              <date type="whenEndEmbargoed">2019-11-08</date>
              <ref type="file" target="https://hal.science/hal-01625025v1/document">
                <date notBefore="2019-11-08"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-01625025v1/file/Solvent_free_mechanochemical_route_for_green_synthesis.pdf" id="file-2355122-2259417">
                <date notBefore="2019-11-08"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="103459">
                <persName>
                  <forename>IMT Mines Albi</forename>
                  <surname>IMT Mines Albi</surname>
                </persName>
                <email type="md5">baf60d7e7735a25e40463f14664b1afd</email>
                <email type="domain">mines-albi.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01625025</idno>
            <idno type="halUri">https://hal.science/hal-01625025</idno>
            <idno type="halBibtex">oliveira:hal-01625025</idno>
            <idno type="halRefHtml">&lt;i&gt;RSC Advances&lt;/i&gt;, 2014, 4 (100), p.56736-56742. &lt;a target="_blank" href="https://dx.doi.org/10.1039/c4ra10489g"&gt;&amp;#x27E8;10.1039/c4ra10489g&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">RSC Advances, 2014, 4 (100), p.56736-56742. &amp;#x27E8;10.1039/c4ra10489g&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2355122-2259417"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="IRD">IRD - Institut de recherche pour le développement</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="MINES-ALBI">Ecole nationale supérieure des Mines d'Albi-Carmaux</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="EMAC">Ecole des Mines d'Albi-Carmaux</idno>
            <idno type="stamp" n="RAPSODEE" corresp="MINES-ALBI">RAPSODEE - UMR5302</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="SPCMIB">Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique</idno>
            <idno type="stamp" n="INSTITUTS-TELECOM">composantes instituts telecom </idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="ICT-CHIMIE">ICT-CHIMIE </idno>
            <idno type="stamp" n="INSTITUT-MINES-TELECOM">Institut Mines Telecom</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Solvent-free mechanochemical route for green synthesis of pharmaceutically attractive phenolhydrazones</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Paulo F. M.</forename>
                    <surname>Oliveira</surname>
                  </persName>
                  <idno type="halauthorid">1245286-0</idno>
                  <affiliation ref="#struct-242220"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Baron</surname>
                  </persName>
                  <email type="md5">c6f155dbc19f32e9273c860862c286f2</email>
                  <email type="domain">mines-albi.fr</email>
                  <idno type="idhal" notation="string">michel-baron</idno>
                  <idno type="idhal" notation="numeric">15986</idno>
                  <idno type="halauthorid" notation="string">6855-15986</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9981-9910</idno>
                  <idno type="IDREF">https://www.idref.fr/078055148</idno>
                  <orgName ref="#struct-469216"/>
                  <affiliation ref="#struct-242220"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Chamayou</surname>
                  </persName>
                  <email type="md5">fff55c9735559609016246fbad0282d2</email>
                  <email type="domain">mines-albi.fr</email>
                  <idno type="idhal" notation="string">alain-chamayou</idno>
                  <idno type="idhal" notation="numeric">179101</idno>
                  <idno type="halauthorid" notation="string">39904-179101</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2060-1837</idno>
                  <idno type="IDREF">https://www.idref.fr/08318080X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAL-1317-2020</idno>
                  <orgName ref="#struct-469216"/>
                  <affiliation ref="#struct-242220"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christiane</forename>
                    <surname>André-Barrès</surname>
                  </persName>
                  <email type="md5">cb372e213eff46198c8bb7805c67cab8</email>
                  <email type="domain">chimie.ups-tlse.fr</email>
                  <idno type="idhal" notation="string">christiane-andre-barres</idno>
                  <idno type="idhal" notation="numeric">178205</idno>
                  <idno type="halauthorid" notation="string">19450-178205</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8973-1875</idno>
                  <idno type="IDREF">https://www.idref.fr/084177942</idno>
                  <affiliation ref="#struct-571"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Brigitte</forename>
                    <surname>Guidetti</surname>
                  </persName>
                  <idno type="halauthorid">1251985-0</idno>
                  <affiliation ref="#struct-571"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Baltas</surname>
                  </persName>
                  <email type="md5">bff7b022110adb42ebd583271ade1883</email>
                  <email type="domain">lcc-toulouse.fr</email>
                  <idno type="idhal" notation="string">michel-baltas</idno>
                  <idno type="idhal" notation="numeric">178036</idno>
                  <idno type="halauthorid" notation="string">6516-178036</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8785-7095</idno>
                  <idno type="IDREF">https://www.idref.fr/03195314X</idno>
                  <affiliation ref="#struct-571"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">KTK-2980</idno>
                <idno type="localRef">DOCA-01</idno>
                <idno type="halJournalId" status="VALID">101697</idno>
                <idno type="issn">2046-2069</idno>
                <title level="j">RSC Advances</title>
                <imprint>
                  <publisher>Royal Society of Chemistry</publisher>
                  <biblScope unit="volume">4</biblScope>
                  <biblScope unit="issue">100</biblScope>
                  <biblScope unit="pp">p.56736-56742</biblScope>
                  <date type="datePub">2014</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1039/c4ra10489g</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="spi">Engineering Sciences [physics]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>A series of hydrazones, as potential therapeutic agents, were successfully synthesized in a vibratory ball-mill from various substituted organic hydrazines and phenol aldehydes. The degree of conversion was increased by high electronic density on the amino group of the hydrazine reactant, as well as low steric hindrance around both reactive sites. In this particular case, the flexibility of the chain bearing the amino reactive site of hydrazine was highlighted as a factor influencing the reaction rate. The results showed that hydrazones could be obtained with more than a 99% transformation, without concurring by-products. This is highly adapted to the synthesis of active pharmaceutical ingredients, requiring a high level of purity. Owing to the fact that neither an environmentally unadvisable reagent nor additives or catalysts were added to achieve the transformation, this synthesis provides a good example and a prefiguration of an efficient green pharmaceutical process.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-242220" status="VALID">
          <idno type="IdRef">155498886</idno>
          <idno type="RNSR">201220448D</idno>
          <idno type="ROR">03cxnrt47</idno>
          <orgName>Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement</orgName>
          <orgName type="acronym">RAPSODEE</orgName>
          <date type="start">2005-01-01</date>
          <desc>
            <address>
              <addrLine>Campus Jarlard 81013 Albi Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://rapsodee.mines-albi.fr</ref>
          </desc>
          <listRelation>
            <relation name="UMR5302" active="#struct-441569" type="direct"/>
            <relation active="#struct-469216" type="direct"/>
            <relation active="#struct-302102" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-571" status="OLD">
          <idno type="IdRef">24018730X</idno>
          <idno type="ISNI">0000 0004 0382 6633</idno>
          <idno type="RNSR">199911759R</idno>
          <orgName>Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique</orgName>
          <orgName type="acronym">SPCMIB</orgName>
          <date type="start">1999-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>bat. 2R1 118 Route de Narbonne 31062 TOULOUSE CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://spcmib.ups-tlse.fr/accueil.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-159253" type="direct"/>
            <relation active="#struct-67872" type="indirect"/>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UAR2599 / FR2599" active="#struct-441569" type="direct"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation name="UMR5068" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-469216" status="VALID">
          <idno type="IdRef">035022116</idno>
          <idno type="ROR">https://ror.org/00bq8vv83</idno>
          <orgName>IMT École nationale supérieure des Mines d'Albi-Carmaux</orgName>
          <orgName type="acronym">IMT Mines Albi</orgName>
          <date type="start">1993-01-01</date>
          <desc>
            <address>
              <addrLine>Campus Jarlard - Route de Teillet81013 ALBI Cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.imt-mines-albi.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-302102" type="direct"/>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-302102" status="VALID">
          <idno type="IdRef">192427156</idno>
          <idno type="ISNI">000000012202567X</idno>
          <idno type="ROR">https://ror.org/025vp2923</idno>
          <idno type="Wikidata">Q27962533</idno>
          <orgName>Institut Mines-Télécom [Paris]</orgName>
          <orgName type="acronym">IMT</orgName>
          <date type="start">2012-03-01</date>
          <desc>
            <address>
              <addrLine>19 Place Marguerite Perey, 91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.imt.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-159253" status="OLD">
          <idno type="IdRef">240309472</idno>
          <idno type="ISNI">0000 0004 4686 8315</idno>
          <idno type="RNSR">200310667L</idno>
          <orgName>Institut de Chimie de Toulouse</orgName>
          <orgName type="acronym">ICT</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-67872" type="direct"/>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UAR2599 / FR2599" active="#struct-441569" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>