<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01621216</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-18T19:08:35+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Deciphering Cell Intrinsic Properties: A Key Issue for Robust Organoid Production</title>
            <author role="aut">
              <persName>
                <forename type="first">Nathalie</forename>
                <surname>Picollet-d'Hahan</surname>
              </persName>
              <idno type="halauthorid">391664-0</idno>
              <affiliation ref="#struct-226010"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Monika E</forename>
                <surname>Dolega</surname>
              </persName>
              <email type="md5">b4a78013808996f62e2df87fb5d521c4</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">monika-dolega</idno>
              <idno type="idhal" notation="numeric">1621919</idno>
              <idno type="halauthorid" notation="string">777463-1621919</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2081-4709</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=fMgS3ewAAAAJ</idno>
              <affiliation ref="#struct-226010"/>
              <affiliation ref="#struct-1041857"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Delphine</forename>
                <surname>Freida</surname>
              </persName>
              <idno type="halauthorid">158384-0</idno>
              <affiliation ref="#struct-226010"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Donald K.</forename>
                <surname>Martin</surname>
              </persName>
              <email type="md5">03a679787b6d67ccc16e0d70389cfdd6</email>
              <email type="domain">imag.fr</email>
              <idno type="idhal" notation="string">donald-k-martin</idno>
              <idno type="idhal" notation="numeric">1041503</idno>
              <idno type="halauthorid" notation="string">820201-1041503</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5913-2372</idno>
              <idno type="IDREF">https://www.idref.fr/160585279</idno>
              <idno type="ISNI">http://isni.org/isni/0000000064595251</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/HSE-9912-2023</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/JOA-2660-2023</idno>
              <idno type="VIAF">https://viaf.org/viaf/94630103</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/HSE-9912-2023</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/JOA-2660-2023</idno>
              <affiliation ref="#struct-1042071"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xavier</forename>
                <forename type="middle">E</forename>
                <surname>Gidrol</surname>
              </persName>
              <idno type="halauthorid">1137707-0</idno>
              <affiliation ref="#struct-226010"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jean-Pierre</forename>
                <surname>Alcaraz</surname>
              </persName>
              <email type="md5">a0a801100af62bdb671a4033595b089a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
            <funder ref="#projanr-38062"/>
            <funder ref="#projanr-34092"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2017-10-23 09:07:59</date>
              <date type="whenModified">2025-12-11 14:53:16</date>
              <date type="whenReleased">2017-10-23 09:07:59</date>
              <date type="whenProduced">2017-11</date>
              <ref type="externalLink" target="https://api.istex.fr/ark:/67375/6H6-1LGJMX6B-H/fulltext.pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="170662">
                <persName>
                  <forename>Jean-Pierre</forename>
                  <surname>Alcaraz</surname>
                </persName>
                <email type="md5">a0a801100af62bdb671a4033595b089a</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01621216</idno>
            <idno type="halUri">https://hal.science/hal-01621216</idno>
            <idno type="halBibtex">picolletdhahan:hal-01621216</idno>
            <idno type="halRefHtml">&lt;i&gt;Trends in Biotechnology&lt;/i&gt;, 2017, 35 (11), pp.1035-1048. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.tibtech.2017.08.003"&gt;&amp;#x27E8;10.1016/j.tibtech.2017.08.003&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Trends in Biotechnology, 2017, 35 (11), pp.1035-1048. &amp;#x27E8;10.1016/j.tibtech.2017.08.003&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-SYNABI" corresp="TIMC-IMAG">SyNaBi : Systèmes Nanobiotechnologiques et Biomimétiques</idno>
            <idno type="stamp" n="IRTSV-BGE" corresp="IRTSV">BIG - Biologie à Grande Échelle (BGE)</idno>
            <idno type="stamp" n="LIPHY" corresp="CNRS">Laboratoire interdisciplinaire de Physique</idno>
            <idno type="stamp" n="BIG" corresp="CEA">Institut de Biosciences et Biotechnologies de Grenoble</idno>
            <idno type="stamp" n="IRIG" corresp="CEA">Institut de Recherche Interdisciplinaire de Grenoble</idno>
            <idno type="stamp" n="CEA-GRE" corresp="CEA">CEA Grenoble</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-COMUE">Université Grenoble Alpes [2016-2019]</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Deciphering Cell Intrinsic Properties: A Key Issue for Robust Organoid Production</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Nathalie</forename>
                    <surname>Picollet-d'Hahan</surname>
                  </persName>
                  <idno type="halauthorid">391664-0</idno>
                  <affiliation ref="#struct-226010"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Monika E</forename>
                    <surname>Dolega</surname>
                  </persName>
                  <email type="md5">b4a78013808996f62e2df87fb5d521c4</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">monika-dolega</idno>
                  <idno type="idhal" notation="numeric">1621919</idno>
                  <idno type="halauthorid" notation="string">777463-1621919</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2081-4709</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=fMgS3ewAAAAJ</idno>
                  <affiliation ref="#struct-226010"/>
                  <affiliation ref="#struct-1041857"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Delphine</forename>
                    <surname>Freida</surname>
                  </persName>
                  <idno type="halauthorid">158384-0</idno>
                  <affiliation ref="#struct-226010"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Donald K.</forename>
                    <surname>Martin</surname>
                  </persName>
                  <email type="md5">03a679787b6d67ccc16e0d70389cfdd6</email>
                  <email type="domain">imag.fr</email>
                  <idno type="idhal" notation="string">donald-k-martin</idno>
                  <idno type="idhal" notation="numeric">1041503</idno>
                  <idno type="halauthorid" notation="string">820201-1041503</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5913-2372</idno>
                  <idno type="IDREF">https://www.idref.fr/160585279</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000064595251</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/HSE-9912-2023</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/JOA-2660-2023</idno>
                  <idno type="VIAF">https://viaf.org/viaf/94630103</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/HSE-9912-2023</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/JOA-2660-2023</idno>
                  <affiliation ref="#struct-1042071"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xavier</forename>
                    <forename type="middle">E</forename>
                    <surname>Gidrol</surname>
                  </persName>
                  <idno type="halauthorid">1137707-0</idno>
                  <affiliation ref="#struct-226010"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">8998</idno>
                <idno type="issn">0167-7799</idno>
                <title level="j">Trends in Biotechnology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">35</biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">1035-1048</biblScope>
                  <date type="datePub">2017-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.tibtech.2017.08.003</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.bio">Life Sciences [q-bio]/Biotechnology</classCode>
              <classCode scheme="halDomain" n="sdv.bc">Life Sciences [q-bio]/Cellular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>We highlight the disposition of various cell types to self-organize into complexorgan-like structures without necessarily the support of any stromal cells,provided they are placed into permissive 3D culture conditions. The goal ofgenerating organoids reproducibly and efficiently has been hampered by poorunderstanding of the exact nature of the intrinsic cell properties at the origin oforganoid generation, and of the signaling pathways governing their differen-tiation. Using microtechnologies like microfluidics to engineer organoidswould create opportunities for single-cell genomics and high-throughputfunctional genomics to exhaustively characterize cell intrinsic properties. Amore complete understanding of the development of organoids wouldenhance their relevance as models to study organ morphology, function,and disease and would open new avenues in drug development and regener-ative medicine.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="department" xml:id="struct-226010" status="OLD">
          <idno type="IdRef">184665868</idno>
          <idno type="RNSR">201119446U</idno>
          <orgName>Laboratoire de Biologie à Grande Échelle</orgName>
          <orgName type="acronym">BGE - UMR S1038</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>17, Rue des Martyrs 38054 Grenoble cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://irig.cea.fr/drf/irig/Pages/Laboratoires/BGE.aspx</ref>
          </desc>
          <listRelation>
            <relation name="U1038" active="#struct-303623" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
            <relation name="DRF/IRIG/DS" active="#struct-555292" type="direct"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1041857" status="OLD">
          <idno type="IdRef">035460849</idno>
          <idno type="ISNI">0000 0000 9272 9931</idno>
          <idno type="RNSR">201122569N</idno>
          <idno type="ROR">https://ror.org/023n9q531</idno>
          <orgName>Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères]</orgName>
          <orgName type="acronym">LIPhy</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>140 rue de la Physique38058 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-liphy.ujf-grenoble.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR5588" active="#struct-441569" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1042071" status="OLD">
          <orgName>Systèmes Nanobiotechnologiques et Biomimétiques</orgName>
          <orgName type="acronym">TIMC-IMAG-SyNaBi</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr/synabi</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042061" type="direct"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-445543" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-445543" status="OLD">
          <idno type="IdRef">188399275</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes [2016-2019]</orgName>
          <orgName type="acronym">UGA [2016-2019]</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-555292" status="VALID">
          <idno type="IdRef">240648846</idno>
          <idno type="RNSR">201923169F</idno>
          <idno type="ROR">https://ror.org/00byxdz40</idno>
          <idno type="Wikidata">Q108737333</idno>
          <orgName>Institut de Recherche Interdisciplinaire de Grenoble</orgName>
          <orgName type="acronym">IRIG</orgName>
          <date type="start">2019-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://hal-cea.archives-ouvertes.fr/IRIG/</ref>
          </desc>
          <listRelation>
            <relation name="DRF/IRIG" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1042061" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-38062" status="VALID">
          <idno type="anr">ANR-11-NANB-0002</idno>
          <idno type="program">Nanobiologies</idno>
          <orgName>FACSBIOMARKER</orgName>
          <desc>Identification et validation de biomarqueurs du cancer de la prostate par ARN interférence à haut débit couplée au FACS</desc>
          <date type="start">2011</date>
        </org>
        <org type="anrProject" xml:id="projanr-34092" status="VALID">
          <idno type="anr">ANR-11-BSV5-0009</idno>
          <idno type="program">BLANC</idno>
          <orgName>BROCOLI</orgName>
          <desc>Echafaudages 3D en polyélectrolytes de culture de cellules prostatiques : un outil d'étude de l'effet du microenvironnement sur le phénotype cancéreux et d'identification de nouveaux biomarqueurs</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>