Different shades of default mode disturbance in schizophrenia: Subnodal covariance estimation in structure and function
Abstract
Schizophrenia is a devastating mental disease with an apparent disruption in the highly
associative default mode network (DMN). Interplay between this canonical network and
others probably contributes to goal-directed behavior so its disturbance is a candidate
neural fingerprint underlying schizophrenia psychopathology. Previous research has
reported both hyper- and hypo-connectivity within the DMN, and both increased and
decreased DMN coupling with the multi-modal saliency network (SN) and dorsal
attention network (DAN). The present study systematically revisited network disruption
in patients with schizophrenia using data-derived network atlases and multivariate
pattern-learning algorithms in a multi-site dataset (n=325). Resting-state fluctuations in
unconstrained brain states were used to estimate functional connectivity, and local
volume differences between individuals were used to estimate structural co-occurrence
within and between the DMN, SN, and DAN. In brain structure and function, sparse
inverse covariance estimates of network structure were used to characterize healthy
and patients with schizophrenia groups, and to identify statistically significant group
differences. Evidence did not confirm that the backbone of the DMN was the primary
driver of brain dysfunction in schizophrenia. Instead, functional and structural
aberrations were frequently located outside of the DMN core, such as in the anterior
temporoparietal junction and precuneus. Additionally, functional covariation analyses
highlighted dysfunctional DMN-DAN coupling, while structural covariation results
highlighted aberrant DMN-SN coupling. Our findings highlight the role of the DMN core
and its relation to canonical networks in schizophrenia and underline the importance of
large-scale neural interactions as effective biomarkers and indicators of how to tailor
psychiatric care to single patients.
Origin : Files produced by the author(s)
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