Tetrakis(trimethylsilyl) ethenylidene-1,1-bisphosphonate: A mild and convenient Michael acceptor for the synthesis of 2-aminoethylidene-1,1- bisphosphonic acids and their potassium salts
Résumé
A straightforward synthesis of highly functionalized 2-aminoethylidene-1,1- bisphosphonic acids via the Michael addition of amines to easily available tetrakis(trimethylsilyl) ethenylidene-1,1-bisphosphonate, H2C=C[P(O) (OTMS)2]2, has been described. The potassium salts of the title compounds were also easily achieved in high yield by reacting the Michael adducts with potassium fluoride. © Georg Thieme Verlag Stuttgart - New York.