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Article Dans Une Revue Blood Purification Année : 2010

Guanidino Compounds as Cause of Cardiovascular Damage in Chronic Kidney Disease: An in vitro Evaluation

Eva Schepers
  • Fonction : Auteur
Griet Glorieux
Laetitia Dou
Nathalie Gayrard
  • Fonction : Auteur
Loïc Louvet
Charlotte Maugard
  • Fonction : Auteur
Pierre Preus
  • Fonction : Auteur
Maria Rodriguez-Ortiz
  • Fonction : Auteur
Angel Argiles
  • Fonction : Auteur
Gerald Cohen
  • Fonction : Auteur
Joachim Jankowski
  • Fonction : Auteur
Vera Jankowski
  • Fonction : Auteur
Ziad Massy
Mariano Rodríguez
  • Fonction : Auteur
Raymond Vanholder
European Uremic Toxin Work Grp
  • Fonction : Auteur

Résumé

Chronic kidney disease is considered a major cause of cardiovascular risk and non-traditional risk factors remain largely unknown. The in vitro toxicity of 10 guanidino compounds (GCs) was evaluated via a standardized approach on different cell systems of relevance in cardiovascular disease. The parameters evaluated were production of reactive oxygen species, expression of surface molecules, cell proliferation, cytotoxicity and calcification. Several GCs had a stimulatory effect on monocytes and granulocytes (SDMA, creatine and guanidinobutyric acid (GBA)). Some GCs (guandine (G), guanidinosuccinic acid (GSA) and SDMA) inhibited endothelial cell proliferation or reduced calcification in osteoblast-like human VSMC (ADMA, GSA and SDMA). Stimulation of osteoclastogenesis could be demonstrated for ADMA, G, guanidinoacetic acid and GBA in a RAW264.7 cell line. No compounds were cytotoxic to AoSMC or endothelial cells, nor influenced their viability. GCs, especially SDMA, likely contribute to cardiovascular complications in uremia, mainly those related to microinflammation and leukocyte activation. Copyright (C) 2010 S. Karger AG, Basel

Dates et versions

hal-01610436 , version 1 (04-10-2017)

Identifiants

Citer

Eva Schepers, Griet Glorieux, Laetitia Dou, Claire Cerini, Nathalie Gayrard, et al.. Guanidino Compounds as Cause of Cardiovascular Damage in Chronic Kidney Disease: An in vitro Evaluation. Blood Purification, 2010, 30 (4), pp.277-287. ⟨10.1159/000320765⟩. ⟨hal-01610436⟩

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