Enantiomer-specific accumulation and depuration of α-hexabromocyclododecane (α-HBCD) in chicken (<i>Gallus gallus</i>) as a tool to identify contamination sources - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemosphere Année : 2017

Enantiomer-specific accumulation and depuration of α-hexabromocyclododecane (α-HBCD) in chicken (Gallus gallus) as a tool to identify contamination sources

Résumé

A LC-ESI(-)-HRMS method dedicated to the analysis of 6 HBCDD enantiomers at trace levels in animal matrices was developed, using a cellulose based stationary phase with a particle size of 2.5 mm. This method was applied to a sample set derived from a kinetic study of α-HBCDD previously conducted in fast- and slow-growing chickens (Gallus gallus domesticus, n = 49, plus controls), in order to study the enantiomer specific accumulation and depuration of α-HBCDD in various tissues. Regarding abdominal adipose tissue, muscle and liver, the average enantiomeric fractions of α-HBCDD (EFα) for continuously exposed groups ranged between 0.434 and 0.467, with standard deviations below 0.014, showing a significant enrichment in (-)α enantiomer even accentuated for slow growing individuals during depuration with EFα reduced by about 0.020. Similar trends were observed for pooled plasma. Then, EFα of circulating plasma α-HBCDD appeared to closely reflect EFα in storage tissues and liver, suggesting some equilibrium. The racemic elimination of α enantiomer in excreta during the contamination phase indicated that no preferential gastrointestinal absorption took place. By contrast, preferential excretion of (-) α-HBCDD from the circulating compartment to the intestinal lumen occurred during the depuration. Finally, the method was applied to samples collected in three chicken farms, selected for total HBCDD levels in muscle in the ng/g range, as a tool to determine whether the contamination occurred ante- or post-mortem, according to the chiral signature. Ante-mortem contamination was hypothesised for 2 farms, with feed being excluded as contamination source.
Fichier principal
Vignette du fichier
hal-01608863-Feidt Cyril.pdf (759.19 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01608863 , version 1 (17-03-2022)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Elsa Omer, Ronan Cariou, Adeline Huneau-Salaün, Gaud Dervilly-Pinel, Elisabeth Baéza, et al.. Enantiomer-specific accumulation and depuration of α-hexabromocyclododecane (α-HBCD) in chicken (Gallus gallus) as a tool to identify contamination sources. Chemosphere, 2017, 180, pp.365-372. ⟨10.1016/j.chemosphere.2017.04.031⟩. ⟨hal-01608863⟩
169 Consultations
69 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More