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Article Dans Une Revue Scientific Reports Année : 2017

Exposure to an acute hypoxic stimulus during early life affects the expression of glucose metabolism-related genes at first-feeding in trout

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Rainbow trout (Oncorhynchus mykiss) is considered a “glucose-intolerant” species. With the aim of programming trout to improve their metabolic use of dietary carbohydrates, we hypothesised that a hypoxic stimulus applied during embryogenesis could later affect glucose metabolism at the first feeding stage. An acute hypoxic stimulus (2.5 or 5.0 mg·L−1 O2) was applied for 24 h to non-hatched embryos or early hatched alevins followed by a challenge test with a high carbohydrate diet at first feeding. The effectiveness of the early hypoxic stimulus was confirmed by the induction of oxygensensitive markers such as egln3. At first-feeding, trout previously subjected to the 2.5 mg·L−1 O2 hypoxia displayed a strong induction of glycolytic and glucose transport genes, whereas these glucose metabolism-related genes were affected much less in trout subjected to the less severe (5.0 mg·L−1 O2) hypoxia. Our results demonstrate that an acute hypoxic stimulus during early development can affect glucose metabolism in trout at first-feeding.
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hal-01608763 , version 1 (26-05-2020)

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Jingwei Liu, Elisabeth Plagnes- Juan, Inge Geurden, Stéphane Panserat, Lucie Marandel. Exposure to an acute hypoxic stimulus during early life affects the expression of glucose metabolism-related genes at first-feeding in trout. Scientific Reports, 2017, 7 (1), pp.1-11. ⟨10.1038/s41598-017-00458-4⟩. ⟨hal-01608763⟩
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