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Article Dans Une Revue Cardiovascular Research Année : 2017

Sex in basic research: concepts in the cardiovascular field

1 CARPAT (UMRS1180) - Signalisation et physiopathologie cardiovasculaire
2 Université Paris Sud (Paris 11)
3 Université Paris-Saclay
4 Institute of Gender in Medicine and Center for Cardiovascular Research
5 Deutsch Zentrum Herz Kreislauf Forsch DZHK
6 Faculté de Médecine [Rangueil]
7 Department of Health Sciences, School of Medicine
8 University of Eastern Piedmont
9 College of Medicine and Veterinary Medicine
10 Institut für Kardiogenetik
11 Department of Biomedical Science
12 Ricercatore TD in Endocrinologia, Dipartimento di Medicina Sperimentale, Sezione di Fisiopatologia Medica
13 International Society for Gender Medicine, Research Center for Medicine, Rabin Medical Center
14 TAU - Tel Aviv University
15 Medizinische Klinik und Poliklinik IV
16 DZD - German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg]
17 BDR - Biologie du Développement et Reproduction
18 Department of General Medicine, Section of Gender Medicine
19 Centre for Gender Medicine and Departments of Obstetrics and Gynecology and Renal Medicine
20 Institut für Medizinische Biometrie und Statistik
21 Universität zu Lübeck = University of Lübeck [Lübeck]
22 Institute for Preclinical Sciences, Veterinary Faculty
23 Institute of Physiology, Medical Faculty
24 National Center for Gender-Specific Medicine
25 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
26 Mayo Clinic
27 Center for Cardiovascular Science
28 Department of Cardiovascular Medicine
29 Institute of Gender and Health
30 Medicinal Chemistry DIFARMA
Claudine Junien
  • Fonction : Auteur
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Virginia M. Miller
  • Fonction : Auteur

Résumé

Women and men, female and male animals and cells are biologically different, and acknowledgement of this fact is critical to advancing medicine. However, incorporating concepts of sex-specific analysis in basic research is largely neglected, introducing bias into translational findings, clinical concepts and drug development. Research funding agencies recently approached these issues but implementation of policy changes in the scientific community is still limited, probably due to deficits in concepts, knowledge and proper methodology. This expert review is based on the EUGenMed project (www.eugenmed.eu) developing a roadmap for implementing sex and gender in biomedical and health research. For sake of clarity and conciseness, examples are mainly taken from the cardiovascular field that may serve as a paradigm for others, since a significant amount of knowledge how sex and oestrogen determine the manifestation of many cardiovascular diseases (CVD) has been accumulated. As main concepts for implementation of sex in basic research, the study of primary cell and animals of both sexes, the study of the influence of genetic vs. hormonal factors and the analysis of sex chromosomes and sex specific statistics in genome wide association studies (GWAS) are discussed. The review also discusses methodological issues, and analyses strength, weaknesses, opportunities and threats in implementing sex-sensitive aspects into basic research.

Dates et versions

hal-01608731 , version 1 (03-10-2017)

Identifiants

Citer

Renée Ventura-Clapier, Elke Dworatzek, Ute Seeland, Georgios Kararigas, Jean-Francois Arnal, et al.. Sex in basic research: concepts in the cardiovascular field. Cardiovascular Research, 2017, 113 (7), pp.711-724. ⟨10.1093/cvr/cvx066⟩. ⟨hal-01608731⟩
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