Cytotoxicity control of silicon nanoparticles by biopolymer coating and ultrasound irradiation for cancer theranostic applications - Archive ouverte HAL
Article Dans Une Revue Nanotechnology Année : 2017

Cytotoxicity control of silicon nanoparticles by biopolymer coating and ultrasound irradiation for cancer theranostic applications

Résumé

Silicon nanoparticles (SiNPs) prepared by mechanical grinding of luminescent porous silicon were coated with a biopolymer (dextran) and investigated as a potential theranostic agent for bioimaging and sonodynamic therapy. Transmission electron microscopy, photoluminescence and Raman scattering measurements of dextran-coated SiNPs gave evidence of their enhanced stability in water. In vitro experiments confirmed the. lower cytotoxicity of the dextran-coated NPs. in comparison with uncoated ones, especially for. high concentrations of about 2 mg ml(-1). Efficient uptake of the NPs. by cancer cells was found using bioimaging in the optical transmittance and photoluminescence modes. Treatment. of the cells with uptaken SiNPs by therapeutic ultrasound for 5-20 min resulted in a strong decrease in. the number of. living cells, while the total number of cells remained nearly unchanged. The obtained data indicate a ` mild' effect of the combined action of ultrasonic irradiation. and SiNPs on cancer cells. The observed results reveal new opportunities for. controlling the photoluminescent and sonosensitizing properties of silicon-based NPs. for applications in the diagnostics and mild therapy of cancer.
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Dates et versions

hal-01607887 , version 1 (03-10-2017)

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a P Sviridov, L A Osminkina, Alexander Kharin, M B Gongalsky, J V Kargina, et al.. Cytotoxicity control of silicon nanoparticles by biopolymer coating and ultrasound irradiation for cancer theranostic applications. Nanotechnology, 2017, 28 (10), pp.105102. ⟨10.1088/1361-6528/aa5b7c⟩. ⟨hal-01607887⟩
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