Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nutrients Année : 2017

Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report

Résumé

A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either L-citrulline or L-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age. The oral glucose tolerance was tested (OGTT) at 70 days of age, and rats were sacrificed at 90 days of age. Pre-weaning citrulline supplementation failed to alter the growth trajectory, OGTT, plasma triglycerides, or fat mass accretion in adulthood; yet, it was associated with increased liver triglycerides, decreased liver total cholesterol, and a distinct liver lipidomic profile that may result in a predisposition to liver disease. We conclude that pre-weaning supplementation with citrulline does not impact early growth, but might impact liver fat metabolism in adulthood upon exposure to a high fructose diet.
Fichier principal
Vignette du fichier
2017_Tran_Nutrients_1.pdf (2.18 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01607137 , version 1 (26-05-2020)

Licence

Paternité

Identifiants

Citer

Nhat Thang Tran, Marie Cécile Alexandre-Gouabau, Anthony Pagniez, Khadija Ouguerram, Clair-Yves Boquien, et al.. Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report. Nutrients, 2017, 9 (4), pp.1-15. ⟨10.3390/nu9040375⟩. ⟨hal-01607137⟩
50 Consultations
24 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More