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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2017

Synthesis and biological evaluation of C-3 aliphatic coumarins as vitamin K antagonists

Sylvie Moebs-Sanchez

Résumé

Since the discovery of Warfarin in the 1940s, the design of new warfarin-derived anticoagulants for rodent management has been challenging, with mainly structural modifications performed on the C3 position of the coumarin skeleton. In order to better understand the pharmacomodulation of such derivatives, we have synthesized a family of C3 (linear and branched) alkyl-4-hydroxycoumarins, which led to the identification of compounds 5e and 5f as potential short-term active anticoagulants.
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hal-01606714 , version 1 (02-10-2017)

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Adrien Montagut-Romans, Manon Boulven, Maiwenn Jacolot, Sylvie Moebs-Sanchez, Claire Hascoet, et al.. Synthesis and biological evaluation of C-3 aliphatic coumarins as vitamin K antagonists. Bioorganic and Medicinal Chemistry Letters, 2017, 27 (7), pp.1598-1601. ⟨10.1016/j.bmcl.2017.02.017⟩. ⟨hal-01606714⟩
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