User experience and usability (UX) form a key part of research and best practice for product and software development. In this paper, the topic is addressed from the perspective of the Digital Humanities (DH) and approaches undertaken in two DH infrastructure projects, DARIAH and CENDARI are presented. Both projects addressed aspects of UX, focusing on the usage of a single software tool, as well as on an integrated research workflow using several tools and devices. The article lists the main factors, gleaned from research undertaken in the projects, that influence usability practices in the DH, and provides possible recommendations on how to approach them.