A comprehensive view of the β-arrestinome - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Endocrinology Année : 2017

A comprehensive view of the β-arrestinome

Résumé

G protein-coupled receptors (GPCRs) are membrane receptors critically involved in sensing the environment and orchestrating physiological processes. As such, they transduce extracellular signals such as hormone, neurotransmitters, ions, and light into an integrated cell response. The intracellular trafficking, internalization, and signaling ability of ligand-activated GPCRs are controlled by arrestins, adaptor proteins that they interact with upon ligand binding. β-arrestins 1 and 2 in particular are now considered as hub proteins assembling multiprotein complexes to regulate receptor fate and transduce diversified cell responses. While more than 400 β-arrestin interaction partners have been identified so far, much remains to be learnt on how discrimination between so many binding partners is accomplished. Here, we gathered the interacting partners of β-arrestins through database mining and manual curation of the literature to map the β-arrestin interactome (β-arrestinome). We discussed several parameters that determine compatible (AND) or mutually exclusive (XOR) binding of β-arrestin interactors, such as structural constraints, intracellular abundance, or binding affinity.
Fichier principal
Vignette du fichier
2017_PCrepieux_FrontiersEndocrinol_1.pdf (4.82 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01604904 , version 1 (26-05-2020)

Licence

Paternité

Identifiants

Citer

Pascale Crépieux, Anne Poupon, Nathalie Langonné, Eric Reiter, Javier Delgado, et al.. A comprehensive view of the β-arrestinome. Frontiers in Endocrinology, 2017, 8, pp.1-11. ⟨10.3389/fendo.2017.00032⟩. ⟨hal-01604904⟩
85 Consultations
42 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More