Non-IgE-mediated food allergies (FA) are highly prevalent within food allergic patients, notably in the first years of life. The most prevalent non-IgE FA are mainly induced by cow’s milk and soya, but may other foods can be involved. Non-IgE FA encompass a wide range of immune-related disorders that differ in prevalence, clinical manifestation and pathophysiology. Although some in vivo models have been developed for their study, further investigations are needed to fully delineate the pathogenic mechanisms involved.