Oxidative cleavage products of lycopene: production and reactivity in a biomimetic experimental model of oxidative stress - Archive ouverte HAL
Chapitre D'ouvrage Année : 2013

Oxidative cleavage products of lycopene: production and reactivity in a biomimetic experimental model of oxidative stress

Résumé

Carotenoids oxidation products are of interest for their possible biological activity. We produced and characterized a series of lycopene oxidative cleavage products by oxidizing lycopene. We synthesized apo-lycopenoids of various polyene chain lengths and terminal functions. Antioxidant activity of apo-lycopenoids was determined using a lipid peroxidation test mimicking oxidative stress in the gastro-intestinal tract. Results allowed us to establish structure-activity relationships of antioxidant protection of apo-lycopenoids in the gastro-intestinal tract. A long carbon chain and a carboxylic acid endgroup conferring an amphiphilic character to the molecule are favorable to the antioxidant activity of apo-lycopenoids.
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Dates et versions

hal-01601772 , version 1 (02-10-2017)

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Catherine Veyrat, Michel Carail, Pascale Goupy, Eric Reynaud, Olivier Dangles. Oxidative cleavage products of lycopene: production and reactivity in a biomimetic experimental model of oxidative stress. Carotenoid Cleavage Products, 1134, Winterhalter P., Ebeler S.E., pp.191-205, 2013, ACS Symposium Series, 978-0-8412-2778-1. ⟨10.1021/bk-2013-1134.ch016⟩. ⟨hal-01601772⟩
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