Bacteria isolated from lung modulate asthma susceptibility in mice
Résumé
Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial
countries. This study evaluates the direct contribution of lung microbial components in allergic
asthma in mice. Germ-Free and Specific-Pathogen-Free mice display similar susceptibilities to House
Dust Mice-induced allergic asthma, indicating that the absence of bacteria confers no protection or
increased risk to aeroallergens. In early life, allergic asthma changes the pattern of lung microbiota,
and lung bacteria reciprocally modulate aeroallergen responsiveness. Primo-colonizing cultivable
strains were screened for their immunoregulatory properties following their isolation from neonatal
lungs. Intranasal inoculation of lung bacteria influenced the outcome of allergic asthma development:
the strain CNCM I 4970 exacerbated some asthma features whereas the pro-Th1 strain CNCM I 4969
had protective effects. Thus, we confirm that appropriate bacterial lung stimuli during early life are
critical for susceptibility to allergic asthma in young adults
Domaines
Sciences du Vivant [q-bio]
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