<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01595231</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-14T18:15:25+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">NMR metabolomic signatures reveal predictive plasma metabolites associated with long-termrisk of developing breast cancer</title>
            <author role="aut">
              <persName>
                <forename type="first">Lucie</forename>
                <surname>Lecuyer</surname>
              </persName>
              <email type="md5">fc0c78b0a9ca7e5ee12e593933d46420</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">1129971</idno>
              <idno type="halauthorid" notation="string">1228183-1129971</idno>
              <affiliation ref="#struct-446175"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Agnès</forename>
                <surname>Victor Bala</surname>
              </persName>
              <idno type="halauthorid">1229225-0</idno>
              <affiliation ref="#struct-152356"/>
              <affiliation ref="#struct-441569"/>
              <affiliation ref="#struct-15786"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mélanie</forename>
                <surname>Deschasaux</surname>
              </persName>
              <email type="md5">ee1602aaf4a52007516d6487002b28cd</email>
              <email type="domain">eren.smbh.univ-paris13.fr</email>
              <idno type="idhal" notation="string">melanie-deschasaux</idno>
              <idno type="idhal" notation="numeric">183648</idno>
              <idno type="halauthorid" notation="string">1113497-183648</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3359-420X</idno>
              <idno type="IDREF">https://www.idref.fr/236007823</idno>
              <affiliation ref="#struct-446175"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nadia</forename>
                <surname>Bouchemal</surname>
              </persName>
              <idno type="halauthorid">221696-0</idno>
              <affiliation ref="#struct-152356"/>
              <affiliation ref="#struct-441569"/>
              <affiliation ref="#struct-15786"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mohamed Nawfal</forename>
                <surname>Triba</surname>
              </persName>
              <idno type="halauthorid">1225376-0</idno>
              <affiliation ref="#struct-152356"/>
              <affiliation ref="#struct-441569"/>
              <affiliation ref="#struct-15786"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Paule</forename>
                <surname>Vasson</surname>
              </persName>
              <email type="md5">926fc2dcdbfa50046aee1270c3cadae3</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="numeric">1117520</idno>
              <idno type="halauthorid" notation="string">854922-1117520</idno>
              <affiliation ref="#struct-491254"/>
              <affiliation ref="#struct-423803"/>
              <affiliation ref="#struct-30615"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Adrien</forename>
                <surname>Rossary</surname>
              </persName>
              <email type="md5">f99029f29cfeab8315dd3e2e214c7ddb</email>
              <email type="domain">uca.fr</email>
              <idno type="idhal" notation="string">adrien-rossary</idno>
              <idno type="idhal" notation="numeric">1237982</idno>
              <idno type="halauthorid" notation="string">457375-1237982</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8311-2419</idno>
              <affiliation ref="#struct-491254"/>
              <affiliation ref="#struct-423803"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aïcha</forename>
                <surname>Demidem</surname>
              </persName>
              <email type="md5">50ddb402ac9d2c160d58ceeb4af1c506</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="numeric">1203012</idno>
              <idno type="halauthorid" notation="string">893801-1203012</idno>
              <affiliation ref="#struct-491254"/>
              <affiliation ref="#struct-423803"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pilar</forename>
                <surname>Galan Hercberg</surname>
              </persName>
              <idno type="halauthorid">935092-0</idno>
              <affiliation ref="#struct-446175"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Serge</forename>
                <surname>Hercberg</surname>
              </persName>
              <email type="md5">622cb98f67075610f3fa82734e3628f7</email>
              <email type="domain">uren.smbh.univ-paris13.fr</email>
              <idno type="idhal" notation="numeric">1136672</idno>
              <idno type="halauthorid" notation="string">160152-1136672</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3168-1350</idno>
              <idno type="IDREF">https://www.idref.fr/02858709X</idno>
              <affiliation ref="#struct-446175"/>
              <affiliation ref="#struct-300210"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valentin</forename>
                <surname>Partula</surname>
              </persName>
              <email type="md5">a5eb63bc030fb7783bb10f0ed02aa926</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1204455</idno>
              <idno type="halauthorid" notation="string">1229226-1204455</idno>
              <affiliation ref="#struct-446175"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurence</forename>
                <surname>Le Moyec</surname>
              </persName>
              <email type="md5">0c856bce120bc31220fb6b9a43af3526</email>
              <email type="domain">univ-evry.fr</email>
              <idno type="idhal" notation="numeric">841803</idno>
              <idno type="halauthorid" notation="string">221701-841803</idno>
              <affiliation ref="#struct-46213"/>
              <affiliation ref="#struct-303623"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bernard</forename>
                <surname>Srour</surname>
              </persName>
              <email type="md5">45e959027c1d013c29b5a00b8018d385</email>
              <email type="domain">eren.smbh.univ-paris13.fr</email>
              <idno type="idhal" notation="string">bsrour</idno>
              <idno type="idhal" notation="numeric">1284322</idno>
              <idno type="halauthorid" notation="string">1229227-1284322</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1277-3380</idno>
              <idno type="IDREF">https://www.idref.fr/249985292</idno>
              <idno type="GOOGLE SCHOLAR">SxvEgtgAAAAJ</idno>
              <affiliation ref="#struct-446175"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thibault</forename>
                <surname>Fiolet</surname>
              </persName>
              <idno type="halauthorid">1229228-0</idno>
              <affiliation ref="#struct-446175"/>
              <affiliation ref="#struct-92114"/>
              <affiliation ref="#struct-303623"/>
              <affiliation ref="#struct-300351"/>
              <affiliation ref="#struct-301664"/>
              <affiliation ref="#struct-300301"/>
              <affiliation ref="#struct-15786"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paule</forename>
                <surname>Latino-Martel</surname>
              </persName>
              <idno type="halauthorid">924127-0</idno>
              <affiliation ref="#struct-446175"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuelle</forename>
                <surname>Kesse-Guyot</surname>
              </persName>
              <email type="md5">b8203980c8246ee82f70d1ea75a23fa3</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">emmanuelle-kesse-guyot</idno>
              <idno type="idhal" notation="numeric">736379</idno>
              <idno type="halauthorid" notation="string">20207-736379</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9715-3534</idno>
              <idno type="IDREF">https://www.idref.fr/18131827X</idno>
              <orgName ref="#struct-577435"/>
              <affiliation ref="#struct-446175"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Savarin</surname>
              </persName>
              <idno type="halauthorid">481405-0</idno>
              <affiliation ref="#struct-152356"/>
              <affiliation ref="#struct-441569"/>
              <affiliation ref="#struct-15786"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mathilde</forename>
                <surname>Touvier</surname>
              </persName>
              <email type="md5">a6aa874386b1015cf41b5f3e16c4dd64</email>
              <email type="domain">eren.smbh.univ-paris13.fr</email>
              <idno type="idhal" notation="numeric">1136541</idno>
              <idno type="halauthorid" notation="string">181748-1136541</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8322-8857</idno>
              <idno type="IDREF">https://www.idref.fr/11033082X</idno>
              <affiliation ref="#struct-446175"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Archive Ouverte</forename>
                <surname>ProdInra</surname>
              </persName>
              <email type="md5">9e5ed7d56b52b3d4383123b1ffb42236</email>
              <email type="domain">inrae.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2017-09-26 21:58:31</date>
              <date type="whenModified">2026-04-25 03:11:58</date>
              <date type="whenReleased">2017-10-02 11:21:49</date>
              <date type="whenProduced">2017-06-22</date>
              <ref type="annex" subtype="poster" n="1" target="https://hal.science/hal-01595231v1/file/2017_Book%20of%20Abstracts_ICTRHN_Clermont_%7BAB90DFB8-0264-440D-BCDE-E82B8117A18E%7D.pdf" id="file-1595231-1646423">
                <date notBefore="2017-09-26"/>
              </ref>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
                <f name="inra_infra_local" notation="string" n="1019-Unité de Nutrition Humaine (UNH)">
                  <string>1019-Unité de Nutrition Humaine (UNH)</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="132775">
                <persName>
                  <forename>Archive Ouverte</forename>
                  <surname>ProdInra</surname>
                </persName>
                <email type="md5">9e5ed7d56b52b3d4383123b1ffb42236</email>
                <email type="domain">inrae.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01595231</idno>
            <idno type="halUri">https://hal.science/hal-01595231</idno>
            <idno type="halBibtex">lecuyer:hal-01595231</idno>
            <idno type="halRefHtml">&lt;i&gt;Fourth International Congress of Translational Research in Human Nutrition ICTRHN 2017&lt;/i&gt;, Jun 2017, Clermont-Ferrand, France. 45 p., 2017, 4th International Congress of Translational Research in Human Nutrition &amp; Cancer:Abstract Book</idno>
            <idno type="halRef">Fourth International Congress of Translational Research in Human Nutrition ICTRHN 2017, Jun 2017, Clermont-Ferrand, France. 45 p., 2017, 4th International Congress of Translational Research in Human Nutrition &amp; Cancer:Abstract Book</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-1595231-1646423"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-PARIS5" corresp="UNIV-PARIS">Université Paris Descartes (Paris 5)</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
            <idno type="stamp" n="PRES_CLERMONT">Université de Clermont</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-EVRY">Université d'Evry-Val d'Essonne</idno>
            <idno type="stamp" n="CNAM">Conservatoire National des Arts et Métiers</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="OCA">Observatoire de la Cote d'Azur</idno>
            <idno type="stamp" n="SUVIMAX" corresp="INSERM">SUVIMAX 1 et 2</idno>
            <idno type="stamp" n="UNH" corresp="PRES_CLERMONT">Unité de Nutrition Humaine</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno>
            <idno type="stamp" n="UBIAE" corresp="UNIV-EVRY">Unité de Biologie Intégrative des Adaptations à l'Exercice</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="UNIV-EVRY-SACLAY" corresp="UNIV-PARIS-SACLAY">UNIV-EVRY-SACLAY</idno>
            <idno type="stamp" n="GALILE" corresp="UNIV-PARIS13">Institut Galilée Université Paris 13</idno>
            <idno type="stamp" n="IBHGC" corresp="UNIV-PARIS13">Institut de Biomécanique Humaine Georges Charpak</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="CRESS">Centre de recherche en épidémiologie et statistiques</idno>
            <idno type="stamp" n="ACT-R" corresp="UNIV-PARIS13">Act'R </idno>
            <idno type="stamp" n="HESAM-CNAM" corresp="HESAM">Conservatoire National des Arts et Métiers - Hesam</idno>
            <idno type="stamp" n="HESAM">Hesam</idno>
            <idno type="stamp" n="ALIMH">Département Alimentation Humaine</idno>
            <idno type="stamp" n="UNH_ECREIN">UNH – Equipe ECREIN</idno>
          </seriesStmt>
          <notesStmt>
            <note type="commentary">SESSION 4 - BREAST CANCER: FROM EXPERIMENTAL APPROACH TO CLINICAL&lt;br/&gt;SESSION 4 - BREAST CANCER: FROM EXPERIMENTAL APPROACH TO CLINICAL</note>
            <note type="audience" n="1">Not set</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">NMR metabolomic signatures reveal predictive plasma metabolites associated with long-termrisk of developing breast cancer</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Lucie</forename>
                    <surname>Lecuyer</surname>
                  </persName>
                  <email type="md5">fc0c78b0a9ca7e5ee12e593933d46420</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">1129971</idno>
                  <idno type="halauthorid" notation="string">1228183-1129971</idno>
                  <affiliation ref="#struct-446175"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Agnès</forename>
                    <surname>Victor Bala</surname>
                  </persName>
                  <idno type="halauthorid">1229225-0</idno>
                  <affiliation ref="#struct-152356"/>
                  <affiliation ref="#struct-441569"/>
                  <affiliation ref="#struct-15786"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mélanie</forename>
                    <surname>Deschasaux</surname>
                  </persName>
                  <email type="md5">ee1602aaf4a52007516d6487002b28cd</email>
                  <email type="domain">eren.smbh.univ-paris13.fr</email>
                  <idno type="idhal" notation="string">melanie-deschasaux</idno>
                  <idno type="idhal" notation="numeric">183648</idno>
                  <idno type="halauthorid" notation="string">1113497-183648</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3359-420X</idno>
                  <idno type="IDREF">https://www.idref.fr/236007823</idno>
                  <affiliation ref="#struct-446175"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nadia</forename>
                    <surname>Bouchemal</surname>
                  </persName>
                  <idno type="halauthorid">221696-0</idno>
                  <affiliation ref="#struct-152356"/>
                  <affiliation ref="#struct-441569"/>
                  <affiliation ref="#struct-15786"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mohamed Nawfal</forename>
                    <surname>Triba</surname>
                  </persName>
                  <idno type="halauthorid">1225376-0</idno>
                  <affiliation ref="#struct-152356"/>
                  <affiliation ref="#struct-441569"/>
                  <affiliation ref="#struct-15786"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Paule</forename>
                    <surname>Vasson</surname>
                  </persName>
                  <email type="md5">926fc2dcdbfa50046aee1270c3cadae3</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="numeric">1117520</idno>
                  <idno type="halauthorid" notation="string">854922-1117520</idno>
                  <affiliation ref="#struct-491254"/>
                  <affiliation ref="#struct-423803"/>
                  <affiliation ref="#struct-30615"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Adrien</forename>
                    <surname>Rossary</surname>
                  </persName>
                  <email type="md5">f99029f29cfeab8315dd3e2e214c7ddb</email>
                  <email type="domain">uca.fr</email>
                  <idno type="idhal" notation="string">adrien-rossary</idno>
                  <idno type="idhal" notation="numeric">1237982</idno>
                  <idno type="halauthorid" notation="string">457375-1237982</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8311-2419</idno>
                  <affiliation ref="#struct-491254"/>
                  <affiliation ref="#struct-423803"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aïcha</forename>
                    <surname>Demidem</surname>
                  </persName>
                  <email type="md5">50ddb402ac9d2c160d58ceeb4af1c506</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="numeric">1203012</idno>
                  <idno type="halauthorid" notation="string">893801-1203012</idno>
                  <affiliation ref="#struct-491254"/>
                  <affiliation ref="#struct-423803"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pilar</forename>
                    <surname>Galan Hercberg</surname>
                  </persName>
                  <idno type="halauthorid">935092-0</idno>
                  <affiliation ref="#struct-446175"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Serge</forename>
                    <surname>Hercberg</surname>
                  </persName>
                  <email type="md5">622cb98f67075610f3fa82734e3628f7</email>
                  <email type="domain">uren.smbh.univ-paris13.fr</email>
                  <idno type="idhal" notation="numeric">1136672</idno>
                  <idno type="halauthorid" notation="string">160152-1136672</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3168-1350</idno>
                  <idno type="IDREF">https://www.idref.fr/02858709X</idno>
                  <affiliation ref="#struct-446175"/>
                  <affiliation ref="#struct-300210"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valentin</forename>
                    <surname>Partula</surname>
                  </persName>
                  <email type="md5">a5eb63bc030fb7783bb10f0ed02aa926</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1204455</idno>
                  <idno type="halauthorid" notation="string">1229226-1204455</idno>
                  <affiliation ref="#struct-446175"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurence</forename>
                    <surname>Le Moyec</surname>
                  </persName>
                  <email type="md5">0c856bce120bc31220fb6b9a43af3526</email>
                  <email type="domain">univ-evry.fr</email>
                  <idno type="idhal" notation="numeric">841803</idno>
                  <idno type="halauthorid" notation="string">221701-841803</idno>
                  <affiliation ref="#struct-46213"/>
                  <affiliation ref="#struct-303623"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bernard</forename>
                    <surname>Srour</surname>
                  </persName>
                  <email type="md5">45e959027c1d013c29b5a00b8018d385</email>
                  <email type="domain">eren.smbh.univ-paris13.fr</email>
                  <idno type="idhal" notation="string">bsrour</idno>
                  <idno type="idhal" notation="numeric">1284322</idno>
                  <idno type="halauthorid" notation="string">1229227-1284322</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1277-3380</idno>
                  <idno type="IDREF">https://www.idref.fr/249985292</idno>
                  <idno type="GOOGLE SCHOLAR">SxvEgtgAAAAJ</idno>
                  <affiliation ref="#struct-446175"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thibault</forename>
                    <surname>Fiolet</surname>
                  </persName>
                  <idno type="halauthorid">1229228-0</idno>
                  <affiliation ref="#struct-446175"/>
                  <affiliation ref="#struct-92114"/>
                  <affiliation ref="#struct-303623"/>
                  <affiliation ref="#struct-300351"/>
                  <affiliation ref="#struct-301664"/>
                  <affiliation ref="#struct-300301"/>
                  <affiliation ref="#struct-15786"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paule</forename>
                    <surname>Latino-Martel</surname>
                  </persName>
                  <idno type="halauthorid">924127-0</idno>
                  <affiliation ref="#struct-446175"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuelle</forename>
                    <surname>Kesse-Guyot</surname>
                  </persName>
                  <email type="md5">b8203980c8246ee82f70d1ea75a23fa3</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">emmanuelle-kesse-guyot</idno>
                  <idno type="idhal" notation="numeric">736379</idno>
                  <idno type="halauthorid" notation="string">20207-736379</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9715-3534</idno>
                  <idno type="IDREF">https://www.idref.fr/18131827X</idno>
                  <orgName ref="#struct-577435"/>
                  <affiliation ref="#struct-446175"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Savarin</surname>
                  </persName>
                  <idno type="halauthorid">481405-0</idno>
                  <affiliation ref="#struct-152356"/>
                  <affiliation ref="#struct-441569"/>
                  <affiliation ref="#struct-15786"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mathilde</forename>
                    <surname>Touvier</surname>
                  </persName>
                  <email type="md5">a6aa874386b1015cf41b5f3e16c4dd64</email>
                  <email type="domain">eren.smbh.univ-paris13.fr</email>
                  <idno type="idhal" notation="numeric">1136541</idno>
                  <idno type="halauthorid" notation="string">181748-1136541</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8322-8857</idno>
                  <idno type="IDREF">https://www.idref.fr/11033082X</idno>
                  <affiliation ref="#struct-446175"/>
                </author>
              </analytic>
              <monogr>
                <meeting>
                  <title>Fourth International Congress of Translational Research in Human Nutrition ICTRHN 2017</title>
                  <date type="start">2017-06-22</date>
                  <date type="end">2017-06-23</date>
                  <settlement>Clermont-Ferrand</settlement>
                  <country key="FR">France</country>
                </meeting>
                <respStmt>
                  <resp>conferenceOrganizer</resp>
                  <name>Centre de Recherche en Nutrition Humaine (CRNH). FRA.</name>
                </respStmt>
                <imprint>
                  <biblScope unit="serie">4th International Congress of Translational Research in Human Nutrition &amp; Cancer:Abstract Book</biblScope>
                  <biblScope unit="pp">45 p.</biblScope>
                  <date type="datePub">2017</date>
                </imprint>
              </monogr>
              <idno type="prodinra">398732</idno>
              <ref target="https://www.reseaunacre.eu/content/download/5523/47665?version=1" type="seeAlso"/>
              <relatedItem target="https://hal.science/hal-01674480v1" type="HasVersion" subtype="http://purl.org/coar/resource_type/c_6670"/>
              <relatedItem target="https://hal.science/hal-01790304v1" type="HasVersion" subtype="http://purl.org/coar/resource_type/c_c94f"/>
              <relatedItem target="https://hal.science/hal-01790303v1" type="HasVersion" subtype="http://purl.org/coar/resource_type/c_6501"/>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">mammary malignant tumor</term>
                <term xml:lang="en">mammary malignant tumor</term>
                <term xml:lang="fr">étude épidémiologique</term>
                <term xml:lang="fr">échantillon de plasma</term>
                <term xml:lang="fr">cancer du sein</term>
                <term xml:lang="fr">étude de cohorte</term>
                <term xml:lang="fr">approche métabolomique</term>
                <term xml:lang="fr">étude épidémiologique</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="vocinrae-old" n="approche métabolomique">approche métabolomique</classCode>
              <classCode scheme="vocinrae-old" n="étude épidémiologique">étude épidémiologique</classCode>
              <classCode scheme="vocinrae-old" n="cancer du sein">cancer du sein</classCode>
              <classCode scheme="vocinrae-old" n="étude de cohorte">étude de cohorte</classCode>
              <classCode scheme="vocinrae-old" n="échantillon de plasma">échantillon de plasma</classCode>
              <classCode scheme="halTypology" n="POSTER">Conference poster</classCode>
              <classCode scheme="halOldTypology" n="POSTER">Conference poster</classCode>
              <classCode scheme="halTreeTypology" n="POSTER">Conference poster</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Purpose:Combination of metabolomics and epidemiological approaches opens new perspectives for groundbreaking discoveries. The aim of the present study was to investigate for the first time whether plasma non-targeted metabolomic profiles, established from a simple blood draw from healthy women, could contribute to predict the risk of developing breast cancer within the following decade and to better understand the aetiology of this complex disease.Methods:A prospective nested case-control study was set up in the SU.VI.MAX cohort, including 206 breast cancer cases diagnosed during a 13y follow-up, and 396 matched controls. Non-targeted NMR metabolomic profiles were established from baseline plasma samples. Multivariable conditional logistic regression models were computed for each individual NMR variable and for combinations of variables derived by principal component analysis.Results: Several metabolomic variables from 1D NMR spectroscopy were associated with breast cancer risk. Women characterized by higher fasting plasma levels of valine, lysine, arginine, glutamine, creatine, creatinine, and glucose and lower plasma levels of lipoproteins, lipids, glycoproteins, acetone, glycerol-derived compounds and unsaturated lipids had a higher risk of developing breast cancer. P-values ranged from 0.00007 (ORT3vsT1=0.37[0.23-0.61] for glycerol-derived compounds) to 0.04 (ORT3vsT1=1.61[1.02-2.55] for glutamine).Conclusion: This prospective study showed that baseline NMR plasma metabolomic signatures reveal predictive metabolites associated with long-term breast cancer risk. These results provide interesting insights to better understand complex mechanisms involved in breast carcinogenesis and evoke plasma metabolic disorders favourable for carcinogenesis initiation. This study may contribute to develop screening strategies for the identification of at-risk women for breast cancer well before symptoms appear</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-446175" status="OLD">
          <idno type="IdRef">196443806</idno>
          <idno type="RNSR">201420738K</idno>
          <orgName>Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité</orgName>
          <orgName type="acronym">CRESS (U1153 / UMR_A_1125 / UMR_S_1153)</orgName>
          <date type="start">2014-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Hôtel-Dieu - 1 place du Parvis Notre-Dame - 75004 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cress-umr1153.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR_A_1125" active="#struct-92114" type="direct"/>
            <relation name="UMR_S_1153" active="#struct-300301" type="direct"/>
            <relation active="#struct-301664" type="direct"/>
            <relation active="#struct-303171" type="direct"/>
            <relation name="U1153" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-152356" status="OLD">
          <idno type="RNSR">201120463Z</idno>
          <idno type="ROR">https://ror.org/0343fpq57</idno>
          <orgName>Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques</orgName>
          <orgName type="acronym">CSPBAT</orgName>
          <date type="start">2011-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Institut Galilée, Université Paris 13, 99 avenue Jean-Baptiste Clément, F-93430 Villetaneuse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris13.fr/cspbat/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-15786" type="direct"/>
            <relation active="#struct-301340" type="direct"/>
            <relation active="#struct-303171" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR7244" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-15786" status="VALID">
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris 13</orgName>
          <orgName type="acronym">UP13</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris13.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-491254" status="OLD">
          <idno type="IdRef">153402962</idno>
          <idno type="RNSR">200017593C</idno>
          <orgName>Unité de Nutrition Humaine</orgName>
          <orgName type="acronym">UNH</orgName>
          <date type="start">2017-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Site INRAE Theix : 63122 Saint-Gènes-Champanelle // Site Clermont : UFR de Médecine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www6.clermont.inrae.fr/unh</ref>
          </desc>
          <listRelation>
            <relation name="UMR1019" active="#struct-92114" type="direct"/>
            <relation name="UMR1019" active="#struct-422708" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-423803" status="VALID">
          <orgName>Centre de Recherche en Nutrition Humaine d'Auvergne</orgName>
          <orgName type="acronym">CRNH d'Auvergne</orgName>
          <date type="start">1992-01-01</date>
          <desc>
            <address>
              <addrLine>58, rue Montalembert - BP 321 63009 Clermont-Ferrand Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.crnh-auvergne.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-30615" status="VALID">
          <idno type="ISNI">0000 0004 1795 1689</idno>
          <idno type="ROR">https://ror.org/02pwnhd33</idno>
          <orgName>Centre Jean Perrin [Clermont-Ferrand]</orgName>
          <orgName type="acronym">UNICANCER/CJP</orgName>
          <desc>
            <address>
              <addrLine>58 rue Montalembert, 63011 Clermont-Ferrand</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cjp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-502406" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300210" status="VALID">
          <idno type="IdRef">030351189</idno>
          <idno type="ROR">https://ror.org/03n6vs369</idno>
          <orgName>Hôpital Avicenne [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://chu93.aphp.fr/hopital-avicenne-bobigny/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-46213" status="OLD">
          <orgName>Unité de biologie intégrative des adaptations à l'exercice</orgName>
          <orgName type="acronym">UBIAE</orgName>
          <date type="start">2010-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Bat Maupertuis Université Evry-Val d'Essonne Bd F Mitterrand, 91 025 Evry Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="EA3872" active="#struct-300306" type="direct"/>
            <relation name="U902" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300351" status="VALID">
          <idno type="IdRef">027404978</idno>
          <idno type="ISNI">0000000121690459</idno>
          <idno type="ROR">https://ror.org/0175hh227</idno>
          <orgName>Conservatoire National des Arts et Métiers [Cnam]</orgName>
          <orgName type="acronym">Cnam</orgName>
          <desc>
            <address>
              <addrLine>292 Rue Saint-Martin, 75003 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnam.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301664" status="OLD">
          <idno type="IdRef">026404788</idno>
          <idno type="ISNI">0000 0001 2188 0914 </idno>
          <idno type="ROR">https://ror.org/0220k9r37</idno>
          <orgName>Université Paris Descartes - Paris 5</orgName>
          <orgName type="acronym">UPD5</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.parisdescartes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300301" status="OLD">
          <idno type="IdRef">027542084</idno>
          <idno type="ISNI">0000000121514068</idno>
          <idno type="ROR">https://ror.org/02n7qrg46</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-303171" status="VALID">
          <idno type="IdRef">19077990X</idno>
          <idno type="ROR">https://ror.org/001z21q04</idno>
          <orgName>Université Sorbonne Paris Cité</orgName>
          <orgName type="acronym">USPC</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301340" status="VALID">
          <orgName>Institut Galilée</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-422708" status="OLD">
          <idno type="IdRef">196200032</idno>
          <idno type="ROR">https://ror.org/01a8ajp46</idno>
          <orgName>Université Clermont Auvergne [2017-2020]</orgName>
          <orgName type="acronym">UCA  [2017-2020]</orgName>
          <date type="start">2017-01-01</date>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>49, bd François-Mitterrand / CS 60032 / 63001 Clermont-Ferrand Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uca.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-502406" status="VALID">
          <orgName>UNICANCER</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75654 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicancer.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300306" status="VALID">
          <idno type="IdRef">030820529</idno>
          <idno type="ISNI">0000000121805818</idno>
          <idno type="ROR">https://ror.org/00e96v939</idno>
          <idno type="Wikidata">Q1531014</idno>
          <orgName>Université d'Évry-Val-d'Essonne</orgName>
          <orgName type="acronym">UEVE</orgName>
          <date type="start">1991-07-22</date>
          <desc>
            <address>
              <addrLine>Boulevard François Mitterrand 91025 Evry Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-evry.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>