It is well established that plant hormones such as auxins, cytokinins (CKs), and abscisic acid (ABA) not only govern important plant physiological traits but are key players in plant–microbe interactions. A poorly appreciated fact, however,is that both microbes and animals produce and perceive plant hormones and their mimics. Moreover, dietary plant hormones impact on human physiological process such as glucose assimilation, inflammation, and cell division. This leads us to wonder whether plant hormones could ensure functions in microbes per se as well as in animal–microbe interactions. We propose here and explore the hypothes is that plant hormones play roles in animal–microbiota relation-ships, with consequences for human health