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Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2002

Functional characterization of Brucella melitensis NorMI, an efflux pump belonging to the multidrug and toxic compound extrusion family

Résumé

Two putative proteins (NorMI and NorMII) similar to the multidrug efflux protein NorM of Vibrio parahaemolyticus are encoded by the Brucella melitensis 16 M genome. We show that a drug-hypersusceptible Escherichia coli strain overexpressing NorMI displays increased resistance to norfloxacin, ciprofloxacin, gentamicin, tetraphenylphosphonium ion, acriflavine, and berberine. This elevated resistance was proven to be mediated by an energy-dependent efflux mechanism. NorMI belongs to the multidrug and toxic compound extrusion family and is the first multidrug efflux protein identified in Brucella spp.
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Dates et versions

hal-01595147 , version 1 (26-09-2017)

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Martine Braibant, Laurence L.A. Guilloteau, Michel Zygmunt. Functional characterization of Brucella melitensis NorMI, an efflux pump belonging to the multidrug and toxic compound extrusion family. Antimicrobial Agents and Chemotherapy, 2002, 46 (9), pp.3050-3053. ⟨10.1128/AAC.46.9.3050-3053.2002⟩. ⟨hal-01595147⟩
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