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Article Dans Une Revue Nature Année : 2016

Human gut microbes impact host serum metabolome and insulin sensitivity

1 Center for Biological Sequence Analysis - Department of Systems Biology
2 Center for Biological Sequence Analysis - Department of Systems Biology
3 Turku Centre for Biotechnology
4 Åbo Akademi University [Turku]
5 Örebro University
6 VTT - VTT Technical Research Centre of Finland
7 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
8 Laboratory of Genomics and Molecular Biomedicine - Department of Biology
9 European Molecular Biology Laboratory
10 Department of Bioscience Engineering
11 Center for the Biology of Disease
12 MetaGenoPolis
13 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
14 Centter for the Biology of Disease
15 Department of Microbiology and Immunology
16 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
17 Steno Diabetes Center
18 Faculty of Pharmacy
19 Institute of Microbiology
20 Centre for the Biology of Disease
21 Faculty of Health and Medical Sciences
22 Research Centre for Prevention and Health - Centre for Health
23 BGI - Beijing Genomics Institute [Shenzhen]
24 Department of Bioscience Engineering
25 Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders
26 MUST - Macau University of Science and Technology
27 Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology
28 Faculty of Health Sciences
29 Molecular Medicine Partnership Unit
30 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
31 Department of Bioinformatics
32 Disease Systems Biology [Copenhagen]
33 Centre for Biotechnology
34 Université Paris-Saclay
35 Centre for Host–Microbiome Interactions - Dental Institute Central Office
36 Guys Hospital
37 GMPA - Génie et Microbiologie des Procédés Alimentaires
38 MICA - Département Microbiologie et Chaîne Alimentaire
39 Danone Research
Emmanuelle Le Chatelier
Florence Levenez
  • Fonction : Auteur
Metahit Consortium
  • Fonction : Auteur
Eric Guédon
Florence Haimet
  • Fonction : Collaborateur
Alexandre Jamet
Sean Kennedy
  • Fonction : Collaborateur
  • PersonId : 1203215
Pierre Léonard
  • Fonction : Collaborateur
Emmanuelle Maguin
Nicolas Pons
  • Fonction : Collaborateur
Johan van Hylckama Vlieg
  • Fonction : Collaborateur

Résumé

Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatusare identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.
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Dates et versions

hal-01594855 , version 1 (26-09-2017)

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Citer

Helle Krogh Pedersen, Valborg Gudmundsdottir, Henrik Bjørn Nielsen, Tuulia Hyotylainen, Trine Nielsen, et al.. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature, 2016, 535 (12), ⟨10.1038/nature18646⟩. ⟨hal-01594855⟩
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