Inflammatory F-2-isoprostane, prostaglandin F-2 alpha, pentraxin 3 levels and breast cancer risk: The Swedish Mammography Cohort - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Prostaglandins, Leukotrienes and Essential Fatty Acids Année : 2016

Inflammatory F-2-isoprostane, prostaglandin F-2 alpha, pentraxin 3 levels and breast cancer risk: The Swedish Mammography Cohort

Résumé

Introduction: Breast cancer is a common cancer among women. Identifying cellular participation of F-2-isoprostane, prostaglandin F-2 alpha, (PGF(2 alpha)) and pentraxin 3 (PTX3) in cancer we evaluated whether their prediagnostic systemic levels that originate from different inflammatory pathways were associated with breast cancer risk. Methods: Seventy-eight breast cancer cases diagnosed after blood collection and 797 controls from the Swedish Mammography Cohort were analysed for urinary F-2-isoprostane, PGF(2 alpha) and plasma PTX3 levels. Results: None of the biomarkers investigated were significantly associated with breast cancer risk. However, there was the suggestion of an inverse association with PTX3 with multivariable adjusted ORs (95% CI) of 0.56 (95% CI=0.29-1.06) and 0.67 (95% CI=0.35-1.28) for the second and third tertiles, respectively (p(trend)=0.20). No associations were observed between F-2-isoprostane (OR=0.87; 95% Cl=048-1.57; p(trend)=0.67) and PGF(2 alpha) metabolite (OR=1.03; 95% CI=0.56-1.88; p(trend)=0.91) comparing the top to bottom tertiles. Conclusions: The systemic levels of F-2-isoprostane, PGF(2 alpha) and PTX3 witnessed in women who later developed breast cancer may not provide prognostic information regarding tumor development in spite of their known involvement in situ cellular context. These observations may indicate that other mechanisms exist in controlling cellular formation of F-2-isoprostane, PGF(2 alpha) and PTX3 and their systemic availability in breast cancer patients
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hal-01594297 , version 1 (26-09-2017)

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Samar Basu, Holly Harris, Alicja Wolk, Adrien Rossary, Florence Caldefie-Chezet, et al.. Inflammatory F-2-isoprostane, prostaglandin F-2 alpha, pentraxin 3 levels and breast cancer risk: The Swedish Mammography Cohort. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2016, 113, pp.28-32. ⟨10.1016/j.plefa.2016.08.005⟩. ⟨hal-01594297⟩
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