Integrating Multi-Functionalities Into Non-Spherical Microparticles Fabricated by Top-Down Approach - Archive ouverte HAL
Journal Articles SCIENCE OF ADVANCED MATERIALS Year : 2015

Integrating Multi-Functionalities Into Non-Spherical Microparticles Fabricated by Top-Down Approach

Abstract

Inorganic micro- and nanoparticles have promising applications in various domains including nanomedicine. However, those fabricated by top-down approach, which has potential for production of size and shape-specific particles, have not been sufficiently exploited in the domain. In this study, we intend to demonstrate the feasibility of integration of multi-functionalities into one non-spherical microparticle by combining photolithography with self-assembled monolayers. Formation of self-assembled monolayers provides versatile chemical functionalities by tailoring the interfaces between the micro- and nanoparticles of any geometry or size and their environment with molecular precision. Herein, square plate-like gold microparticles were region-selectively functionalized by self-assembled monolayers with two different active terminal moieties such as amine and biotin. Further modification allowed integrating multi-functionalities including fluorescent probes and biomolecules into one particle, which has been confirmed by fluorescence microscopy and scanning electron microscopy. These results suggest a potential use of such non-spherical micro- and nanoparticles with multi-functionalities for target-specific diagnostics and therapeutics.
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hal-01593306 , version 1 (26-09-2017)

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Maria Genua, Nora Reinhardt, Jérôme Faure-Vincent, Roberto Calemczuk, Thierry Livache, et al.. Integrating Multi-Functionalities Into Non-Spherical Microparticles Fabricated by Top-Down Approach. SCIENCE OF ADVANCED MATERIALS, 2015, 7 (9), pp.1779-1784. ⟨10.1166/sam.2015.2429⟩. ⟨hal-01593306⟩
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