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Article Dans Une Revue Molecular Immunology Année : 2017

C1q: A fresh look upon an old molecule

Résumé

Originally discovered as part of C1, the initiation component of the classical complement pathway, it is now appreciated that C1q regulates a variety of cellular processes independent of complement activation. C1q is a complex glycoprotein assembled from 18 polypeptide chains, with a C-terminal globular head region that mediates recognition of diverse molecular structures, and an N-terminal collagen-like tail that mediates immune effector mechanisms. C1q mediates a variety of immunoregulatory functions considered important in the prevention of autoimmunity such as the enhancement of phagocytosis, regulation of cytokine production by antigen presenting cells, and subsequent alteration in T-lymphocyte maturation. Furthermore, recent advances indicate additional roles for C1q in diverse physiologic and pathologic processes including pregnancy, tissue repair, and cancer. Finally, C1q is emerging as a critical component of neuronal network refinement and homeostatic regulation within the central nervous system. This review summarizes the classical functions of C1q and reviews novel discoveries within the field.

Dates et versions

hal-01592495 , version 1 (25-09-2017)

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Nicole M. Thielens, Francesco Tedesco, Suzanne S. Bohlson, Christine Gaboriaud, Andrea J. Tenner. C1q: A fresh look upon an old molecule. Molecular Immunology, 2017, 89, pp.73 - 83. ⟨10.1016/j.molimm.2017.05.025⟩. ⟨hal-01592495⟩
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