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Journal Articles International Journal of Pharmaceutics Year : 2015

Texture analysis as a tool to study the kinetics of wet agglomeration processes

Silvia Nalesso
  • Function : Author
Carlo Codemo
  • Function : Author
Erica Franceschinis
  • Function : Author
Nicola Realdon
  • Function : Author
Andrea Santomaso
  • Function : Author

Abstract

In this work wet granulation experiments were carried out in a planetary mixer with the aim to develop a novel analytical tool based on surface texture analysis. The evolution of a simple formulation (300 g of microcrystalline cellulose with a solid binders pre-dispersed in water) was monitored from the very beginning up to the end point and information on the kinetics of granulation as well as on the effect of liquid binder amount were collected. Agreement between texture analysis and granules particle size distribution obtained by sieving analysis was always found. The method proved to be robust enough to easily monitor the process and its use for more refined analyses on the different rate processes occurring during granulation is also suggested.
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Dates and versions

hal-01591577 , version 1 (21-09-2017)

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Silvia Nalesso, Carlo Codemo, Erica Franceschinis, Nicola Realdon, Riccardo Artoni, et al.. Texture analysis as a tool to study the kinetics of wet agglomeration processes. International Journal of Pharmaceutics, 2015, 485 (1-2), pp. 61-69. ⟨10.1016/j.ijpharm.2015.03.007⟩. ⟨hal-01591577⟩
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