With the considerable increase of data and the diversity of the user’s needs, the personalisation of information becomes a real challenge in medical information systems. In this context, we propose a technique to personalise medical information, based on a profile modeling. This technique consists in: 1) building user’s profile and 2) using these profiles in the medical information adaptation. The first step considers three dimensions: access right, skills, preferences. The second step consists in filtering data in response to user query according to profile content. Thus, users access relevant information personalized in the appropriate form at the right time with minimal user effort.