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Poster De Conférence Année : 2015

Early digestive microbiota characteristics is correlated to susceptibility to post-weaning diarrhea

Résumé

Gut microbiota can improve animal health and well-being. Our study aimed to explore whether the early composition and profile of the intestinal microbiota may determine the sensitivity to post-weaning diarrhea in pigs. Two farms were selected based on their breading performances, standard (SP) and degraded (DP). Forty pigs (4 animals/litter and 5 litters/farm), selected according to their birth weight and estimated colostrum intake, were weaned at postnatal day (PND) 21 and housed in a dirty experimental environment to challenge their resistance to post-weaning diarrhea. A time course study of diversity and composition of fecal microbiota was performed using a 16S rRNA approach (CE-SSCP, qPCR). Colon transcriptome was studied in PND50 pigs. Thirteen pigs from the SP farm contracted Enterobacteriaceae-associated post-weaning diarrhea while 7 pigs from the SP farm and all pigs from the DP farm were resistant (P<0.05). Microbiota of PND7 resistant piglets from both farms was retrospectively characterized with a high diversity (P<0.05). An unstable dynamic of equitability evolution over time was observed in diarrheic piglets. At PND7 the inter-litter similarity of microbiota differed according to the prevalence of intra-litter post-weaning diarrhea. Analysis of differentially expressed genes in diarrheic pigs showed a up-regulation of cellular oxidative stress and proinflammatory pathways in comparison to resistant pigs. This modulation was correlated to the microbiota diversity at PND7. In conclusion early bacterial diversity may determine sensitivity to post-weaning diarrhea of piglets via a long-term modulation of intestinal functions. Ongoing analysis of epigenetic markers would give more insights on such mechanisms.

Domaines

Biologie animale
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Dates et versions

hal-01575940 , version 1 (21-08-2017)

Licence

Paternité - Partage selon les Conditions Initiales

Identifiants

  • HAL Id : hal-01575940 , version 1
  • PRODINRA : 404507

Citer

Samir Dou, Pascale Gadonna-Widehem, Dounia Hamoudi, Larbi Rhazi, Lyes Lakhal, et al.. Early digestive microbiota characteristics is correlated to susceptibility to post-weaning diarrhea. 13. Digestive physiology of pigs, May 2015, Varsovie, Poland. , 2015, Book of abstracts. ⟨hal-01575940⟩
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