Quantification of biventricular myocardial strain from magnetic resonance images of pulmonary hypertensive patients using hyperelastic warping
Résumé
Pulmonary hypertension (PH) is a disease resulting from
restricted flow in the pulmonary arterial circulation. This results in an
increase in pulmonary vascular resistance. Left untreated, the disease
leads to right ventricular (RV) failure, which is the most common
cause of death in PH patients. The quantification of RV function is
important for clinical management of PH patients, with clinical
studies showing that the RV function is a major determinant of the
functional capacity and prognosis in PH patients. Recent studies have
demonstrated that the RV strain is associated with the RV function,
and is a potentially useful prognostic marker in PH patients.
Compared to quantifying strain in the left ventricle (LV), which can
be approximated by a truncated ellipsoid, the in vivo quantitative
assessment of the strain in the RV is challenging because of its
complex geometry and thin wall. Here, we describe the application of
a hyperelastic warping technique for quantifying RV strain in PH
patients using regular CINE-MR images, which has the potential to
overcome these challenges.
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