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Article Dans Une Revue Advanced Functional Materials Année : 2014

Polymer-aptamer hybrid emulsion templating yields bioresponsive nanocapsules

D. Kedracki
  • Fonction : Auteur
P. Maroni
  • Fonction : Auteur
H. Schlaad
  • Fonction : Auteur

Résumé

This article describes the synthesis of a DNA-polymer, being the nucleotide sequence an aptamer selected in vitro to target specifically the immunoglobulin E (IgE) protein, an allergy biomarker. Subsequent to coupling to poly(2-alkyl-2-oxazoline) with N-Boc protected amino acid side chains, the resulting amphiphilic DNA-polymer hybrid composed of the water-soluble DNA fragment grafted to the hydrophobic polymer segment can be regarded as a high molecular weight analogue of a surfactant. It is demonstrated that the copolymer-aptamer stabilizes efficiently submicrometer size oil-in-water and water-in-oil emulsions, by dynamic light scattering, microscopy, and reflectometry. Particularly interesting is that the aptamer remains functional after coupling to a polymer backbone, stabilization of the emulsion droplets, and locking of the structure subsequent to cross-linking polymerization. The resulting nanocapsules still target specifically the IgE protein. The biological-stimulus responsiveness of the structures is of high potential for future developments of carriers for sustained and targeted delivery. An IgE-aptamer polymer hybrid efficiently stabilizes an emulsion. Since they specifically recognize immunoglobulin E, the resulting nanocapsules are biological-stimulus responsive. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Dates et versions

hal-01564227 , version 1 (18-07-2017)

Identifiants

Citer

D. Kedracki, P. Maroni, H. Schlaad, C. Vebert-Nardin. Polymer-aptamer hybrid emulsion templating yields bioresponsive nanocapsules. Advanced Functional Materials, 2014, 24 (8), pp.1133-1139. ⟨10.1002/adfm.201302475⟩. ⟨hal-01564227⟩
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