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Article Dans Une Revue Chemical Biology and Drug Design Année : 2006

The prion protein: Structural features and related toxic peptides

E. Benedetti
  • Fonction : Auteur
F. Rossi
  • Fonction : Auteur
B. Tizzano
  • Fonction : Auteur
P. Palladino
  • Fonction : Auteur
R. Ragone
  • Fonction : Auteur
E. Urso
  • Fonction : Auteur
M. Maffia
  • Fonction : Auteur
M. Ruvo
  • Fonction : Auteur

Résumé

Prion diseases are characterized by the conversion of the physiological cellular form of the prion protein (PrPC) into an insoluble, partially protease-resistant abnormal scrapie form (PrPSc). PrP C is normally expressed in mammalian cell and is highly conserved among species, although its role in cellular function remains elusive. The conversion of PrPC to PrPSc parallels a conformational change of the polypeptide from a predominantly α-helical to a highly β-sheet secondary structure. The pathogenesis and molecular basis of the consequent nerve cell loss are not understood. Limited structural information is available on aggregate formation by this protein as the possible cause of these diseases and on its toxicity. This brief overview focuses on the large amount of structure-activity studies based on the prion fragment approach, hinging on peptides derived from the unstructured N-terminal and globular C-terminal domains. It is well documented that most of the fragments with regular secondary structure, with the exception of helices 1 and 3, possess a high β-sheet propensity and tendency to form β-sheet-like aggregates. In this context, helix 2 plays a crucial role because it is able to adopt both misfolded and partially helical conformation. However, only a few mutants are able to display its intrinsic neurotoxicity. © 2006 The Authors.

Domaines

Chimie

Dates et versions

hal-01563753 , version 1 (18-07-2017)

Identifiants

Citer

E. Benedetti, F. Rossi, Luisa Ronga, B. Tizzano, P. Palladino, et al.. The prion protein: Structural features and related toxic peptides. Chemical Biology and Drug Design, 2006, 68 (3), pp.139-147. ⟨10.1111/j.1747-0285.2006.00427.x⟩. ⟨hal-01563753⟩
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