<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01560281</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T01:12:04+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Clear cell renal cell carcinoma: a comparative study of histological and chromosomal characteristics between primary tumors and their corresponding metastases</title>
            <author role="aut">
              <persName>
                <forename type="first">Julien</forename>
                <surname>Dagher</surname>
              </persName>
              <idno type="halauthorid">798614-0</idno>
              <affiliation ref="#struct-74673"/>
              <affiliation ref="#struct-182194"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Solène-Florence</forename>
                <surname>Kammerer-Jacquet</surname>
              </persName>
              <email type="md5">922c62a50c2aa3bd568812f659e996bc</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1020252</idno>
              <idno type="halauthorid" notation="string">1079082-1020252</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6623-741X</idno>
              <affiliation ref="#struct-146305"/>
              <affiliation ref="#struct-182194"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frédéric</forename>
                <surname>Dugay</surname>
              </persName>
              <idno type="halauthorid">796620-0</idno>
              <affiliation ref="#struct-187162"/>
              <affiliation ref="#struct-74673"/>
              <affiliation ref="#struct-182194"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marion</forename>
                <surname>Beaumont</surname>
              </persName>
              <idno type="halauthorid">1076062-0</idno>
              <affiliation ref="#struct-74673"/>
              <affiliation ref="#struct-182194"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexandra</forename>
                <surname>Lespagnol</surname>
              </persName>
              <idno type="halauthorid">316102-0</idno>
              <affiliation ref="#struct-301327"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurence</forename>
                <surname>Cornevin</surname>
              </persName>
              <idno type="halauthorid">976081-0</idno>
              <affiliation ref="#struct-74673"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Grégory</forename>
                <surname>Verhoest</surname>
              </persName>
              <idno type="halauthorid">312416-0</idno>
              <affiliation ref="#struct-29416"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karim</forename>
                <surname>Bensalah</surname>
              </persName>
              <idno type="halauthorid">312083-0</idno>
              <affiliation ref="#struct-29416"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nathalie</forename>
                <surname>Rioux-Leclercq</surname>
              </persName>
              <email type="md5">99ad269fdb2963edb662127e62b71d02</email>
              <email type="domain">chu-rennes.fr</email>
              <idno type="idhal" notation="numeric">857400</idno>
              <idno type="halauthorid" notation="string">312148-857400</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3042-7510</idno>
              <affiliation ref="#struct-146305"/>
              <affiliation ref="#struct-182194"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Marc-Antoine</forename>
                <surname>Belaud-Rotureau</surname>
              </persName>
              <idno type="halauthorid">512944-0</idno>
              <affiliation ref="#struct-74673"/>
              <affiliation ref="#struct-182194"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2017-07-11 14:30:22</date>
              <date type="whenModified">2026-04-15 15:02:09</date>
              <date type="whenReleased">2017-07-11 14:30:22</date>
              <date type="whenProduced">2017-07</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01560281</idno>
            <idno type="halUri">https://univ-rennes.hal.science/hal-01560281</idno>
            <idno type="halBibtex">dagher:hal-01560281</idno>
            <idno type="halRefHtml">&lt;i&gt;Virchows Archiv&lt;/i&gt;, 2017, 471 (1), pp.107-115. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s00428-017-2124-0"&gt;&amp;#x27E8;10.1007/s00428-017-2124-0&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Virchows Archiv, 2017, 471 (1), pp.107-115. &amp;#x27E8;10.1007/s00428-017-2124-0&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="IGDR">Institut Génétique et Développement de Rennes</idno>
            <idno type="stamp" n="IRSET">Institut de Recherche en Santé, Environnement et Travail</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="IRSET-SMS" corresp="IRSET">STRESS, MEMBRANE AND SIGNALING</idno>
            <idno type="stamp" n="IRSET-CCII" corresp="IRSET">CHEMICAL CONTAMINANTS, IMMUNITY AND INFLAMMATION</idno>
            <idno type="stamp" n="IRSET-TREC" corresp="IRSET">TRANSCRIPTION, ENVIRONMENT and CANCER (TREC)</idno>
            <idno type="stamp" n="IRSET-HIAEC" corresp="IRSET">HEPATOTROPIC INFECTIOUS AGENTS AND ENVIRONMENTAL COFACTORS</idno>
            <idno type="stamp" n="IRSET-SMLF" corresp="IRSET">SIGNALING AND MODELING IN LIVER FIBROSIS</idno>
            <idno type="stamp" n="IRSET-ERD" corresp="IRSET">EPIDEMIOLOGICAL RESEARCH ON  ENVIRONMENT, REPRODUCTION AND DEVELOPMENT</idno>
            <idno type="stamp" n="IRSET-VCER" corresp="IRSET">ENVIRONMENT VIRAL ET CHIMIQUE &amp; REPRODUCTION</idno>
            <idno type="stamp" n="IRSET-NEED" corresp="IRSET">NEUROENDOCRINE EFFECTS OF ENDOCRINE DISRUPTORS</idno>
            <idno type="stamp" n="IRSET-TNGC" corresp="IRSET">Recherches épidémiologiques sur l'environnement, la reproduction et le développement</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="IRSET-8" corresp="IRSET">DEJUCQ-RAINSFORD - Physiologie et physiopathologie du tractus urogénital</idno>
            <idno type="stamp" n="TEST-UNIV-RENNES">TEST Université de Rennes</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Clear cell renal cell carcinoma: a comparative study of histological and chromosomal characteristics between primary tumors and their corresponding metastases</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Julien</forename>
                    <surname>Dagher</surname>
                  </persName>
                  <idno type="halauthorid">798614-0</idno>
                  <affiliation ref="#struct-74673"/>
                  <affiliation ref="#struct-182194"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Solène-Florence</forename>
                    <surname>Kammerer-Jacquet</surname>
                  </persName>
                  <email type="md5">922c62a50c2aa3bd568812f659e996bc</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1020252</idno>
                  <idno type="halauthorid" notation="string">1079082-1020252</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6623-741X</idno>
                  <affiliation ref="#struct-146305"/>
                  <affiliation ref="#struct-182194"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frédéric</forename>
                    <surname>Dugay</surname>
                  </persName>
                  <idno type="halauthorid">796620-0</idno>
                  <affiliation ref="#struct-187162"/>
                  <affiliation ref="#struct-74673"/>
                  <affiliation ref="#struct-182194"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marion</forename>
                    <surname>Beaumont</surname>
                  </persName>
                  <idno type="halauthorid">1076062-0</idno>
                  <affiliation ref="#struct-74673"/>
                  <affiliation ref="#struct-182194"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexandra</forename>
                    <surname>Lespagnol</surname>
                  </persName>
                  <idno type="halauthorid">316102-0</idno>
                  <affiliation ref="#struct-301327"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurence</forename>
                    <surname>Cornevin</surname>
                  </persName>
                  <idno type="halauthorid">976081-0</idno>
                  <affiliation ref="#struct-74673"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Grégory</forename>
                    <surname>Verhoest</surname>
                  </persName>
                  <idno type="halauthorid">312416-0</idno>
                  <affiliation ref="#struct-29416"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karim</forename>
                    <surname>Bensalah</surname>
                  </persName>
                  <idno type="halauthorid">312083-0</idno>
                  <affiliation ref="#struct-29416"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nathalie</forename>
                    <surname>Rioux-Leclercq</surname>
                  </persName>
                  <email type="md5">99ad269fdb2963edb662127e62b71d02</email>
                  <email type="domain">chu-rennes.fr</email>
                  <idno type="idhal" notation="numeric">857400</idno>
                  <idno type="halauthorid" notation="string">312148-857400</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3042-7510</idno>
                  <affiliation ref="#struct-146305"/>
                  <affiliation ref="#struct-182194"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Marc-Antoine</forename>
                    <surname>Belaud-Rotureau</surname>
                  </persName>
                  <idno type="halauthorid">512944-0</idno>
                  <affiliation ref="#struct-74673"/>
                  <affiliation ref="#struct-182194"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">10730</idno>
                <idno type="issn">0945-6317</idno>
                <idno type="eissn">1432-2307</idno>
                <title level="j">Virchows Archiv</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="volume">471</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">107-115</biblScope>
                  <date type="datePub">2017-07</date>
                  <date type="dateEpub">2017-05-09</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s00428-017-2124-0</idno>
              <idno type="pubmed">28488172</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Chromosome</term>
                <term xml:lang="en">clear cell renal cell carcinoma</term>
                <term xml:lang="en">metastasis</term>
                <term xml:lang="en">CGH</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Clear cell renal cell carcinoma (ccRCC) has a poor prognosis with a 50% risk of metastases. Little is known about the phenotypic and molecular profiles of metastases regarding their corresponding primary tumors. This study aimed to screen phenotypic and genotypic differences between metastases and their corresponding primary tumors. We selected four cases with available frozen material. The histological, immunohistochemical (VEGFA, CD31, SMA, Ki67, p53, PAR-3), FISH (VHL gene), next-generation sequencing (VHL and c-MET genes), multiplex ligation-dependent probe amplification, and array-(comparative genomic hybridization) CGH analyses were realized. Metastases were nodal, hepatic (synchronous), adrenal, and pulmonary (metachronous). High-grade tumor cells were significantly more frequent in metastases (p = 0.019). Metastases and high-grade zones of primary tumors shared similar characteristics compared to low-grade zones: a lower microscopic vascular density (43.5 vs 382.5 vessels/mm(2); p = 0.0027), a higher expression of VEGF (73 vs 10%, p = 0.045), Ki67 (37.6 vs 8.3%; p = 0.011), and p53 (54 vs 10.6%; p = 0.081), and a cytoplasmic and membranous PAR-3 staining. Metastases exhibited more chromosomal imbalances than primary tumors in total (18.75 ± 6.8; p = 0.044) with more genomic gains (13.5 ± 7; p = 0.013). The loss of chromosome 9 and gain of Xq were found in both primary tumors and metastases but gains of loci or chromosomes 2p, 3q, 5, 8q, 12, and 20 were only found in metastases. The VHL gene status was similar in each tumor couple. Although metastases and primary tumors share common histological features, this study highlights chromosomal differences specific to metastases which could be involved in ccRCC metastatic evolution.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-74673" status="VALID">
          <orgName>Service de Cytogénétique et de Biologie Cellulaire</orgName>
          <desc>
            <address>
              <addrLine>2 av du Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-301327" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-182194" status="VALID">
          <idno type="IdRef">177984775</idno>
          <idno type="RNSR">201722263E</idno>
          <idno type="ROR">https://ror.org/01p178v10</idno>
          <idno type="Wikidata">Q30261433</idno>
          <orgName>Institut de recherche en santé, environnement et travail</orgName>
          <orgName type="acronym">Irset</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>263 avenue Général Leclerc 35042 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.irset.org</ref>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-301986" type="direct"/>
            <relation name="U1085" active="#struct-303623" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-146305" status="VALID">
          <orgName>Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes]</orgName>
          <desc>
            <address>
              <addrLine>CHU Rennes, 2, rue Henri-le-Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-301327" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-187162" status="VALID">
          <idno type="IdRef">178579254</idno>
          <idno type="ISNI">000000040609882X</idno>
          <idno type="RNSR">201220436R</idno>
          <idno type="ROR">https://ror.org/036xhtv26</idno>
          <orgName>Institut de Génétique et Développement de Rennes</orgName>
          <orgName type="acronym">IGDR</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://igdr.univ-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation name="UMR6290" active="#struct-441569" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-29416" status="VALID">
          <orgName>Service d'urologie [Rennes] = Urology [Rennes]</orgName>
          <desc>
            <address>
              <addrLine>CHU, 2 rue Henri Le Guilloux 35033 Rennes cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301327" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301986" status="VALID">
          <idno type="IdRef">161356915</idno>
          <idno type="ISNI">0000 0001 1943 5037</idno>
          <idno type="ROR">https://ror.org/01sc83v92</idno>
          <orgName>École des Hautes Études en Santé Publique</orgName>
          <orgName type="acronym">EHESP</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ehesp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-453207" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes</orgName>
          <orgName type="acronym">Biosit : Biologie - Santé - Innovation Technologique</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rennes - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>