This paper proposes a realistic and global simulation to predict the behavior of a Radio over Fiber (RoF) system before its realization. In this work we consider a 2 ×× 2 Multiple-Input Multiple-Output (MIMO) Orthogonal Frequency Division Multiplexing (OFDM) RoF system at 60 GHz. This system is based on Spatial Diversity (SD) which increases reliability (decreases probability of error) and Spatial Multiplexing (SMX) which increases data rate, but not necessarily reliability. The 60 GHz MIMO channel model employed in this work based on a lot of measured data and statistical analysis named Triple-S and Valenzuela (TSV) model. To the authors best knowledge; it is the first time that this type of TSV channel model has been employed for 60 GHz MIMO-RoF system. We have evaluated and compared the performance of this system according to the diversity technique, modulation schemes, and channel coding rate for Line-Of-Sight (LOS) desktop environment. The SMX coded is proposed as an intermediate system to improve the Signal to Noise Ratio (SNR) and the data rate. The resulting 2 ×× 2 MIMO-OFDM SMX system achieves a higher data rate up to 70 Gb/s with 64QAM and Forward Error Correction (FEC) limit of 10−3 over 25-km fiber transmission followed by 3-m wireless transmission using 7 GHz bandwidth of millimeter wave band.