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Article Dans Une Revue Journal of Alzheimer's Disease Année : 2015

Leukocyte Telomere Length in Alzheimer's Disease Patients with a Different Rate of Progression

Enzo Tedone
  • Fonction : Auteur
Beatrice Arosio
  • Fonction : Auteur
Federico Colombo
Evelyn Ferri
  • Fonction : Auteur
Delphine Asselineau
  • Fonction : Auteur
Francois Piette
  • Fonction : Auteur
Cristina Gussago
  • Fonction : Auteur
Joel Belmin
Sylvie Pariel
  • Fonction : Auteur
Khadija Benlhassan
  • Fonction : Auteur
Martina Casati
  • Fonction : Auteur
Anne Bornand
  • Fonction : Auteur
Paolo Dionigi Rossi
  • Fonction : Auteur
Paolo Mazzola
  • Fonction : Auteur
Giorgio Annoni
  • Fonction : Auteur
Laura Porretti
  • Fonction : Auteur
Dorothy H. Bray
  • Fonction : Auteur
Daniela Mari
  • Fonction : Auteur

Résumé

Background: Age and short leukocyte telomeres have been associated with a higher risk of Alzheimer's disease (AD). Inflammation is involved in AD and it is suggested that anti-inflammatory interleukin-10 (IL-10) may partly antagonize these processes. Objective: The aim is to correlate telomere length (TL) in peripheral blood mononuclear cells (PBMC) from patients with AD to disease progression rate. Moreover, we evaluated whether TL was associated with IL-10 production by unstimulated or amyloid-beta (A beta)-stimulated PBMC. Methods: We enrolled 31 late-onset AD and 20 age-matched healthy elderly (HE). After a two-year follow-up period, patients were retrospectively evaluated as slow-progressing (ADS) (Mini Mental State Examination (MMSE) decline over the two years of follow-up <= 3 points) or fast progressing AD (ADF) (MMSE decline >= 5 points). TL was measured by flow cytometry and in vitro IL-10 production by enzyme-linked immunosorbent assay. Results: TL (mean +/- SD) for HE, ADS, and ADFwas 2.3 +/- 0.1, 2.0 +/- 0.1, and 2.5 +/- 0.1 Kb, respectively. ADS showed a shorter TL compared to HE (p = 0.034) and to ADF (p = 0.005). MMSE decline correlated with TL in AD (R-2 = 0.284; p = 0.008). We found a significant difference in IL-10 production between unstimulated and A beta-stimulated PBMC from ADS (40.7 +/- 13.7 versus 59.0 +/- 27.0; p = 0.004) but not from ADF (39.7 +/- 14.4 versus 42.2 +/- 22.4). HE showed a trend toward significance (47.1 +/- 25.4 versus 55.3 +/- 27.9; p = 0.10). Conclusion: PBMC from ADF may be characterized by an impaired response induced by A beta and by a reduced proliferative response responsible for the longer telomeres. TL might be a contributing factor in predicting the rate of AD progression.

Dates et versions

hal-01545784 , version 1 (23-06-2017)

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Enzo Tedone, Beatrice Arosio, Federico Colombo, Evelyn Ferri, Delphine Asselineau, et al.. Leukocyte Telomere Length in Alzheimer's Disease Patients with a Different Rate of Progression. Journal of Alzheimer's Disease, 2015, 46 (3), pp.761-769. ⟨10.3233/JAD-142808⟩. ⟨hal-01545784⟩
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