Article Dans Une Revue Journal of Cell Science Année : 2016

Regulation of myogenesis by environmental hypoxia

Michele Beaudry
  • Fonction : Auteur
Magdalena Hidalgo
  • Fonction : Auteur
Thierry Launay
  • Fonction : Auteur
Thierry Darribere
  • Fonction : Auteur

Résumé

In aerobic organisms, oxygen is a critical factor for tissue and organ morphogenesis from embryonic development throughout the adult life. It regulates various intracellular pathways involved in cellular metabolism, proliferation, cell survival and fate. Organisms or tissues rapidly respond to changes in oxygen availability by activating complex signalling networks, which culminate in the control of mRNA translation and/or gene expression. This Commentary presents the effects of hypoxia during embryonic development, myoblasts and satellite cell proliferation and differentiation in vertebrates. We also outline the relationship between Notch, Wnt and growth factor signalling pathways, as well as the post-transcriptional regulation of myogenesis under conditions of hypoxia.

Dates et versions

hal-01539795 , version 1 (15-06-2017)

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Michele Beaudry, Magdalena Hidalgo, Thierry Launay, Valerie Bello, Thierry Darribere. Regulation of myogenesis by environmental hypoxia. Journal of Cell Science, 2016, 129 (15), pp.2887-2896. ⟨10.1242/jcs.188904⟩. ⟨hal-01539795⟩
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